Original Communications:

Fabio Pacelli, Maurizio Bossola, Laura Teodori, Maria Luisa Trinca, Antonio Tortorelli, Fausto Rosa, and Giovan Battista Doglietto

Parenteral Nutrition Does Not Stimulate Tumor Proliferation in Malnourished Gastric Cancer Patients
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 451-455. [Abstract] [Full Text] [PDF]  
Tumor cell proliferation was evaluated in 20 malnourished gastric cancer patients randomized to receive the oral hospital standard diet (control group) or the oral standard hospital diet associated with parenteral nutrition (PN) support (treatment group). Tumor proliferation was assessed before and after nutrition treatment using flow cytometry and the measurement of the uptake of bromodeoxyuridine (BduR) by cells. The mean percentage of tumor cells incorporating BduR was similar in the control and in the treatment groups, as well as the percentage of S-phase cells documented by flow cytometry. The present study suggests that PN does not stimulate tumor proliferation in malnourished patients affected by gastric cancer.

Michelle Mignon, Anne-Marie Beaufrère, Lydie Combaret, and Dominique Meynial-Denis

Does Long-Term Intermittent Treatment With Glutamine Improve the Well-being of Fed and Fasted Very Old Rats?
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 456-462. [Abstract] [Full Text] [PDF]  
Glutamine has a specific role in very old rats. Long-term intermittent treatment with glutamine began before advanced age maintained gut mass and decreased the up-regulated glutamine synthetase activity in very old rats in the fed state.

Roberto Ghiselli, Andrea Giacometti, Oscar Cirioni, Federico Mocchegiani, Carmela Silvestri, Fiorenza Orlando, Wojciech Kamysz, Alberto Licci, Piotr Nadolski, Agnese Della Vittoria, Jerzy Lukasiak, Giorgio Scalise, and Vittorio Saba

Pretreatment With the Protegrin IB-367 Affects Gram-Positive Biofilm and Enhances the Therapeutic Efficacy of Linezolid in Animal Models of Central Venous Catheter Infection
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 463-468. [Abstract] [Full Text] [PDF]  
IB-367 is a novel anti-microbial which displays potential as an adjunctive agent to linezolid in the treatment of central venous catheter infections using the antibiotic-lock technique.

Reuven Friedmann, Helena Feldman, and Moshe Sonnenblick

Misplacement of Percutaneously Inserted Gastrostomy Tube Into the Colon: Report of 6 Cases and Review of the Literature
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 469-476. [Abstract] [Full Text] [PDF]  
Our report describes 28 cases from our series as well as from the literature, with the different clinical presentations and mechanisms, and includes a discussion of the various treatment approaches.

Kenneth A. Kudsk, F. Enrique Gomez, Woodae Kang, and Chikara Ueno

Enteral Feeding of a Chemically Defined Diet Preserves Pulmonary Immunity but Not Intestinal Immunity: The Role of Lymphotoxin β Receptor
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 477-481. [Abstract] [Full Text] [PDF]  
Type and route of diet differentially influence molecular events in the gut and lung mucosal immune system. Any enteral feeding maintains lung lymphotoxin β receptor (LTβR) expression, an important control molecule for immune integrity, whereas intestinal expression requires a complex diet. LTβR explains preservation of respiratory tract immunity when intestinal immunity is compromised.

Maaike W. Schaart, Adrianus C. J. M. de Bruijn, Dick Tibboel, Ingrid B. Renes, and Johannes B. van Goudoever

Dietary Protein Absorption of the Small Intestine in Human Neonates
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 482-486. [Abstract] [Full Text] [PDF]  
Neonatal bowel resection leads to loss of absorptive and protective surface and may thus cause malabsorption of dietary nutrients. We quantified intestinal adaptation at the net dietary protein absorptive level. This study demonstrated that the dietary protein absorption capacity of the small intestine is intact after neonatal intestinal surgery.

Jonathan Blau, Shanthy Sridhar, Susan Mathieson, and Anupama Chawla

Effects of Protein/Nonprotein Caloric Intake on Parenteral Nutrition–Associated Cholestasis in Premature Infants Weighing 600–1000 Grams
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 487-490. [Abstract] [Full Text] [PDF]  
Causes of parenteral nutrition-associated cholestasis continue to be elusive. Protein to nonprotein calorie ratio was an etiology in the development of cholestasis in premature infants weighing 600–1000 g.

Jakub Visek, Michal Zourek, Silvie Lacigova, and Zdenek Rusavy

Influence of Fiber on Glycemic Index of Enteral Nutrition
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 491-495. [Abstract] [Full Text] [PDF]  
This study is focused on evaluation of the influence of fiber-enriched enteral nutrition on postprandial glycemia using glycemic indices. We did not prove that addition of fiber into enteral nutrition affects postprandial glycemia.

Jie Cao, Shi-Min Luo, Lijian Liang, and Jiaming Lai

Effects of Parenteral Nutrition Without and With Growth Hormone on Growth Hormone/Insulin-Like Growth Factor-1 Axis After Hepatectomy in Hepatocellular Carcinoma With Liver Cirrhosis
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 496-501. [Abstract] [Full Text] [PDF]  
Postoperative hepatic insulin-like growth factor-1 (IGF-1) production may be severely disturbed in patients with liver cirrhosis, and the impaired IGF-1 production contributes to the suppressed postoperative protein metabolism in liver cirrhosis. Recombinant human growth hormone (rhGH) + parenteral nutrition can ameliorate changes in the growth hormone/IGF-1 axis after hepatectomy for hepatocellular carcinoma (HCC) in the setting of liver cirrhosis. Short-term use of rhGH in HCC patients with cirrhosis after operation may be safe.

Bo-Guang Fan

Parenteral Nutrition Prolongs the Survival of Patients Associated With Malignant Gastrointestinal Obstruction
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 508-510. [Abstract] [Full Text] [PDF]  
PN is indicated in patients with a dysfunctional gastrointestinal tract, but its role in the survival of patients with advanced cancer is still controversial. The present study shows that PN can obtain a longer survival period for the patients with gastrointestinal obstruction caused by advanced cancer.

Sassan Pazirandeh, Pei-Ra Ling, Mario Ollero, Fredric Gordon, David L. Burns, and Bruce R. Bistrian

Supplementation of Arachidonic Acid Plus Docosahexaenoic Acid in Cirrhotic Patients Awaiting Liver Transplantation: A Preliminary Study
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 511-516. [Abstract] [Full Text] [PDF]  
Supplementation with small amounts of arachidonic acid and docosahexaenoic acid in patients with advanced liver disease is well tolerated and increases their respective levels in serum phospholipids.

Demet Koc, Arzu Gercek, Rasim Gencosmanoglu, and Nurdan Tozun

Percutaneous Endoscopic Gastrostomy in the Neurosurgical Intensive Care Unit: Complications and Outcome
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 517-520. [Abstract] [Full Text] [PDF]  
Percutaneous endoscopic gastrostomy (PEG) may be required for long-term feeding of patients having persistently depressed neurological status or severe lower cranial nerve palsies in the neurosurgical intensive care units. The purpose of the present study is to report our experience with PEG in these patients.

Brief Communications:

Emanuele Cereda, Mauro Turrini, Denis Ciapanna, Laura Marbello, Angelo Pietrobelli, and Ettore Corradi

Assessing Energy Expenditure in Cancer Patients: A Pilot Validation of a New Wearable Device
(SAGE) JPEN J Parenter Enteral Nutr 2007 31: 502-507. [Abstract] [Full Text] [PDF]  
SenseWear Armband is a new wearable device for measuring energy expenditures. Although it was previously validated only on healthy subjects, its use preliminarily appears promising also for the cancer patient, providing there is accurate estimation of resting energy expenditures and useful information about total daily energy expenditures.

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