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Journal of Parenteral and Enteral Nutrition
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A New Intravenous Emulsion Containing Medium-Chain Triglyceride: Studies of its Metabolic Effects in the Perioperative Period Compared with a Conventional Long-Chain Triglyceride Emulsion

P.J. Crowe

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, England

A.R. Dennison

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, England

G.T. Royle

Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, England

The effects of carbohydrate, lipid, and nitrogen metabolism of recently available lipid emulsions containing either 50% medium-chain triglyceride (MCT) and 50% long-chain triglyceride (LCT) or 100% LCT were compared in elective surgical patients. Postoperative urinary urea excretion was similar during isocaloric MCT/LCT and LCT infusions (1.9 mg/kg/min) and was decreased compared with a standard infusion of 5% glucose (1 mg/kg/min). Plasma glucose and insulin concentrations were similar during both lipid and low dose glucose infusions. However, plasma triglyceride and nonesterified fatty acid concentrations were decreased during the MCT/LCT infusion compared with the LCT infusion, suggesting that the MCT/LCT emulsion was cleared from the circulation faster than pure LCT. Ketone body concentrations were similar during all three infusions. MCT/LCT emulsion can be safely infused perioperatively and has similar nitrogen conserving properties to LCT in these circumstances (Journal of Parenteral and Enteral Nutrition 9:720-724, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 6, 720-724 (1985)
DOI: 10.1177/0148607185009006720
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