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Journal of Parenteral and Enteral Nutrition
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Clinical Trial

The Effects of Oral Soybean Phospholipid on Serum Total Cholesterol, Plasma Triglyceride, and Serum High-Density Lipoprotein Cholesterol Concentrations in Hyperlipidemia

L. Ovesen

Nutrition Laboratory, Kommunehospitalet, Copenhagen, Denmark

K. Ebbesen

Nutrition Laboratory, Kommunehospitalet, Copenhagen, Denmark

E.S. Olesen

Nutrition Laboratory, Kommunehospitalet, Copenhagen, Denmark

In a randomized, double-blind, cross-over trial soybean phospholipid and placebo, 18 g daily for 6 wk, were given orally to 20 patients on long-term treatment with standard lipid lowering diets. The effect of this treatment on serum total cholesterol and high-density lipoprotein cholesterol and plasma triglyceride was studied. After 6 wk mean (±SE) cholesterol concentration was decreased by 0.54 (±0.19) mmol/ liter in phospholipid-treated as compared to placebo-treated patients (p < 0.02). The decrease in serum cholesterol was significant (p < 0.02) only in patients assigned to receive phospholipid before placebo. A highly significant increase (p < 0.001) followed the withdrawal of phospholipid. No effect on triglyceride and high-density lipoprotein cholesterol concentrations was demonstrated. (Journal of Parenteral and Enteral Nutrition 9:716-719, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 6, 716-719 (1985)
DOI: 10.1177/0148607185009006716
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