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Journal of Parenteral and Enteral Nutrition
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The Clinical Evaluation of Plasma Fibronectin as a Marker for Nutritional Depletion and Repletion and as a Measure of Nitrogen Balance

Donald F. Kirby, M.D.

Nutritional Support Services and the Gastroenterology Section, Department of Medicine of Northwestern Memorial Hospital, VA Lakeside Hospital Medical Center, and Northwestern University Medical School, Chicago, Illinois

Robert J. Marder, M.D.

Nutritional Support Services and the Gastroenterology Section, Department of Medicine of Northwestern Memorial Hospital, VA Lakeside Hospital Medical Center, and Northwestern University Medical School, Chicago, Illinois

Robert M. Craig, M.D.

Nutritional Support Services and the Gastroenterology Section, Department of Medicine of Northwestern Memorial Hospital, VA Lakeside Hospital Medical Center, and Northwestern University Medical School, Chicago, Illinois

Rebecca Eskildsen, R.D.

Nutritional Support Services and the Gastroenterology Section, Department of Medicine of Northwestern Memorial Hospital, VA Lakeside Hospital Medical Center, and Northwestern University Medical School, Chicago, Illinois

Patricia Middaugh, R.D.

Nutritional Support Services and the Gastroenterology Section, Department of Medicine of Northwestern Memorial Hospital, VA Lakeside Hospital Medical Center, and Northwestern University Medical School, Chicago, Illinois

Plasma fibronectin has been suggested as a possible marker for nutritional repletion or depletion. This study was undertaken to evaluate the usefulness of plasma fibronectin in patients who received intense nutritional support. Twenty-seven patients referred to our Nutritional Support Services were followed for 3 to 5 wk; 22 received parenteral hyperalimentation alone, two received enteral alone, and three received a combination of both. Plasma fibronectin, serum albumin, serum transferrin, total lymphocyte counts, and 24-hr urine nitrogen balance studies were performed weekly; anthropometric measurements were performed every other week. Plasma fibronectin concentration, measured by laser nephelometry, showed a significant rise (p < 0.005) in all patients after 1 wk of nutritional therapy; however, there was no significant difference among the subsequent weeks. Plasma fibronectin did not correlate with nitrogen balance studies, serum albumin, or total lymphocyte counts. A correlation between serum transferrin and plasma fibronectin was found not to be clinically useful. Thus, plasma fibronectin is sensitive to nutritional repletion after 1 wk of therapy, but is not useful thereafter. The relationship among nutritional status, immunologic function, plasma fibronectin, and other serum proteins are discussed (Journal of Parenteral and Enteral Nutrition 9:705-708, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 6, 705-708 (1985)
DOI: 10.1177/0148607185009006705
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