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Blood Hemoglobin: A Possible Predictor of Central Venous Catheter-Related Thrombosis in Parenteral Nutrition

Department of Surgery, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden

Bo Brismar, M.D.

Department of Surgery, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden

The biochemical records of 43 patients given nutritional support via a central venous catheter (CVC) for between 7 and 111 days (mean 28 days) without anticoagulant therapy were reviewed. On completion of the parenteral nutrition, phlebography was performed via the CVC. Patients developing CVC-related thrombosis (22/43, 51% ) were assigned to group I and those without this phlebographic finding (21/ 43, 49% ) to group II. The blood (B-) hemoglobin concentration before catheterization was higher in group I than in group II, the values being 121 ± 16 (mean ± SD) and 106 ± 13 g/liter, respectively. An initial B-hemoglobin level above 127 g/liter showed a high positive accuracy of prediction for CVC-related thrombosis and on this basis 89% (8/9) of the patients were correctly assigned to group I, whereas an initial B-hemoglobin level below 111 g/liter showed a lower accuracy of prediction for a normal phlebographic status and on this basis 71% (12/ 17) of the patients were correctly assigned to group II. The specificity of the test criteria—B—hemoglobin >127 and <111 g/liter—was high, with values of 95% (20/21) and 77% (17/22), respectively, whereas the sensitivity was low; only 36% (8/22) of group I had an initial B-hemoglobin above 127 g/liter and in group II 57% (12/21) recorded a value below 111 g/liter. It is concluded that if a patient has an initial B-hemoglobin concentration of more than 127 g/liter there is a high risk that CVC-related thrombosis will develop during parenteral nutrition lasting 1 wk or more. (Journal of Parenteral and Enteral Nutrition 9:471-473, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 4, 471-473 (1985)
DOI: 10.1177/0148607185009004471


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