Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Parenteral and Enteral Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Bozzetti, F.
Right arrow Articles by Terno, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bozzetti, F.
Right arrow Articles by Terno, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

"Nutritional" Markers as Prognostic Indicators of Postoperative Sepsis in Cancer Patients

Federico Bozzetti, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Silvana Migliavacca, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Giuseppe Gallus, M.A.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Giovanni Radaelli, M.A.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Adriana Scotti, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Maria Grazia Bonalumi, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Mario Ammatuna, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Carmen Sequeira, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Giovanni Terno, M.D.

Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

A study was undertaken to identify the nutritional parameters associated with a high risk of postoperative sepsis. The nutritional status of 162 cancer patients subjected to clean or clean-contaminated elective surgery was preoperatively evaluated according to the following parameters: percentage weight loss, arm circumference, triceps skinfold, arm muscle circumference, creatinine-height index, total serum protein, serum albumin, total iron-binding capacity, cholinesterase, peripheral lymphocytes, complement C3-C4 components, and skin tests. Patients were followed postoperatively according to a precise protocol to classify them as infected or noninfected. Postoperative sepsis was present in 40 patients who had significantly different mean values for four nutritional parameters from those of 114 patients with no complications, ie, total serum protein, 6.60 vs 6.99 g/dl, p = 0.008; serum albumin, 3.39 vs 3.66 g/dl, p = 0.001; total iron-binding capacity 301.32 vs 337.17 mmg/dl, p = 0.006; and cholinesterase, 2389.77 vs 2770.10 mU/ml, p = 0.005. Moreover, the relative risk and the attributable risk for these variables were evaluated and the significance was tested by the {chi}2 test. By using multiple logistic analysis it appeared that only total serum protein and total iron-binding capacity gave an independent contribution to the risk of postoperative sepsis, while serum albumin disappeared and cholinesterase became non significant when the contribution of the first two variables was accounted for. It was also possible to identify, in a small number of patients, combinations of two variables that were associated with a very high risk of postoperative sepsis. Although these parameters appear to be reliable indicators of postoperative infections, we do not know if they are only simple nonspecific markers of malnutrition or whether they are directly involved in host defense mechanisms. This point warrants further discussion (Journal of Parenteral and Enteral Nutrition 9:464-470, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 4, 464-470 (1985)
DOI: 10.1177/0148607185009004464
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
M. Braga, L. Gianotti, G. Radaelli, M. Cristallo, P. Baccari, S. Dal Cin, and V. Di Carlo
Evaluation of the Predictive Performance of Nutritional Indicators by Receiver-Operating Characteristic Curve Analysis
JPEN J Parenter Enteral Nutr, November 1, 1991; 15(6): 619 - 624.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
F. Bozzetti
Review: Effects of Artificial Nutrition on the Nutritional Status of Cancer Patients
JPEN J Parenter Enteral Nutr, July 1, 1989; 13(4): 406 - 420.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
M. Braga, P. Baccari, S. Scaccabarozzi, E. Fiacco, G. Radaelli, G. Gallus, S. Dipalo, V. Dicarlo, and M. Cristallo
Prognostic Role of Preoperative Nutritional and Immunological Assessment in the Surgical Patient
JPEN J Parenter Enteral Nutr, March 1, 1988; 12(2): 138 - 142.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
D. T. Dempsey and J. L. Mullen
Prognostic Value of Nutritional Indices
JPEN J Parenter Enteral Nutr, September 1, 1987; 11(5_suppl): 109S - 114S.
[PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
F. Bozzetti
Nutritional Assessment from the Perspective of a Clinician
JPEN J Parenter Enteral Nutr, September 1, 1987; 11(5_suppl): 115S - 121S.
[Abstract] [PDF]