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Journal of Parenteral and Enteral Nutrition
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Elimination of Lipofundin S during the Intravenous Fat Tolerance Test in Patients with Low, Medium, and High Fasting Triglyceride Concentrations

W. Leonhardt

Department of Internal Medicine, Medical Academy "Carl Gustav Carus," Dresden, GDR

U. Julius

Department of Internal Medicine, Medical Academy "Carl Gustav Carus," Dresden, GDR

J. Schulze

Department of Internal Medicine, Medical Academy "Carl Gustav Carus," Dresden, GDR

M. Hanefeld

Department of Internal Medicine, Medical Academy "Carl Gustav Carus," Dresden, GDR

H. Haller

Department of Internal Medicine, Medical Academy "Carl Gustav Carus," Dresden, GDR

The intravenous fat tolerance test with Lipofundin S (0.5 ml of 20% emulsion/kg body weight) was performed in 22 male nondiabetic patients. According to their fasting triglycerides (TG), the patients were arranged into three groups: low (<2.8 mmol/liter), medium (2.8-5.7 mmol/liter), and high (>5.7 mmol/liter) concentrations. Fractional elimination rates of injected Lipofundin S decreased from 11.08 in low TG to 4.57%/min in high TG; they were positively correlated with fasting levels of high-density lipoprotein cholesterol but negatively with those of TG. The same pattern of correlations was observed with fractional catabolic rates of endogenous TG as measured after injection of tritium-labeled glycerol. The intravenous Lipofundin S load effected transient TG and free fatty acid elevations which were delayed in high TG. The elimination mechanisms of injected Lipofundin S and of endogenous TG are compared. (Journal of Parenteral and Enteral Nutrition 9:461-463, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 4, 461-463 (1985)
DOI: 10.1177/0148607185009004461
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Home page
 JPEN J Parenter Enteral NutrHome page
U. Julius and W. Leonhardt
Elimination and Metabolism of a Fat Emulsion Containing Medium Chain Triglycerides (Lipofundin MCT 10%)
JPEN J Parenter Enteral Nutr, March 1, 1988; 12(2): 116 - 120.
[Abstract] [PDF]