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Administration of Fat Emulsions with Nutritional Mixtures from the 3-Liter Delivery System in Total Parenteral Nutrition

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

R.G. Rees, B.MED.Sc., M.R.C.P.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

D.H. Patil, M.B.B.S., M.R.C.P.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

P.P. Keohane, M.B.B.S., M.R.C.P.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

H.A. Attrill, S.R.N.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

P.G. Frost, M.Sc., M.R.C.PATH.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

A.R. Cribb, B.PHARM, M.P.S.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

D.B.A. Silk, M.D., F.R.C.P.

Departments of Gastroenterology and Nutrition, Pharmacy and Chemical Pathology, Central Middlesex Hospital, London, England

A series of studies was performed to test the efficacy and safety of a parenteral lipid emulsion, Lipofundin S, when given as part of a complete nutritive mixture from the three-liter bag total parenteral nutrition (TPN) delivery system. In vitro stability studies with mixtures corresponding to high and low nutritional intakes showed the fat emulsion to be stable during refrigerated storage for at least 6 days. The clinical use of Lipofundin S in 3-liter TPN bags was studied in 39 consecutive patients requiring TPN, and there were no untoward side-effects. Nitrogen balance was maintained in patients with pancreatitis, those recovering postoperatively, and those with miscellaneous conditions. However, patients with multiple trauma remained in negative balance. The ability of sera, from patients on TPN to agglutinate Lipofundin S was compared to that from healthy controls, and acutely ill patients not on TPN. Patients on TPN showed a higher degree of in vitro creaming than acutely ill controls, and this may have been related to the severity of the underlying illness. These studies suggest that this parenteral lipid emulsion can be safely administered to patients requiring TPN when given from the 3-liter bag delivery system. (Journal of Parenteral and Enteral Nutrition 9:456-460, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 4, 456-460 (1985)
DOI: 10.1177/0148607185009004456


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