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Journal of Parenteral and Enteral Nutrition
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Evaluation of the Effect of Arginine-Enriched Amino Acid Solution on Tumor Growth

K. Tachibana, PH.D.

Department of Nutrition, School of Medicine, The University of Tokushima

K. Mukai

Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan

I. Hiraoka

Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan

S. Moriguchi, PH.D.

Department of Nutrition, School of Medicine, The University of Tokushima

S. Takama

Department of Nutrition, School of Medicine, The University of Tokushima

Y. Kishino, M.D.

Department of Nutrition, School of Medicine, The University of Tokushima

To investigate the effect of arginine-enriched solution on tumor growth and metastasis, rats were infused with solutions containing 5.5 and 0.66% arginine for 8 days. Infusions were started at the same time of subcutaneous transplant of Yoshida sarcoma. Arginine-rich solution suppressed tumor growth at an early stage and prevented metastases. to the liver and kidney. In addition, arginine supplements enhanced the phagocytic activity of alveolar macrophages. It also resulted in maintenance of a positive nitrogen balance and prevented the increases in the levels of several amino acids observed in the control group. The suppressive effect of arginine-enriched solution on tumor growth may be due to its activation of the immunologic system, in which the phagocytic activity of macrophages probably participates. (Journal of Parenteral and Enteral Nutrition 9:428-434, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 4, 428-434 (1985)
DOI: 10.1177/0148607185009004428
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