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Journal of Parenteral and Enteral Nutrition
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Sensitivity and Specificity of Liver Function Tests in the Detection of Parenteral Nutrition-Associated Cholestasis

Amin A. Nanji, M.D., F.R.C.P. C

Department of Laboratory Medicine, Ottawa General Hospital and Departments of Pathology and Biochemistry, University of Ottawa, Ottawa, Ontario

Frank H. Anderson, M.D., F.R.C.P. C

Department of Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, B.C., Canada

We carried out a study to determine which of the liver function tests was the most sensitive and/or specific in detecting parenteral nutrition associated cholestasis. The tests utilized were alkaline phosphatase, {gamma}-glutamyl transpeptidase, cholyglycine, sulfolithocholylglycine, and bilirubin. Fifty-nine patients with no prior evidence of liver dysfunction were studied. We found {gamma}-glutamyl transpeptidase to be the most sensitive (89.5%) and also the least specific (61.9% specificity). Specificity of {gamma}-glutamyl transpeptidase was improved when it was combined with alkaline phosphatase. We recommend the combination of these two enzymes as the most cost effective way of detecting parenteral nutrition-associated cholestasis. (Journal of Parenteral and Enteral Nutrition 9:307-308, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 3, 307-308 (1985)
DOI: 10.1177/0148607185009003307
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