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Journal of Parenteral and Enteral Nutrition
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The Effect of Major Thermal Injury on Plasma Ketone Body Levels

W.C. Abbott, M.D.

University of New Mexico School of Medicine, Albuquerque, New Mexico

W.R. Schiller, M.D.

St. Joseph's Hospital and Medical Center, Phoenix, Arizona, The Medical College of Ohio at Toledo, Toledo, Ohio

C.L. Long, PH.D.

The Baptist Medical Centers, Birmingham, Alabama

R.H. Birkhahn, PH.D.

University of New Mexico School of Medicine, Albuquerque, New Mexico

W.S. Blakemore, M.D.

The Baptist Medical Centers, Birmingham, Alabama

Eleven patients with more than 30% total body surface burns were studied during 3 days of starvation and three more days of unrestricted feeding following their injury. All patients developed marked protein mobilization as demonstrated by 3rd day urine nitrogen excretion of 17.1 g daily compared to control excretion of 11.8 g N daily. As a group, the patients failed to mount the expected ketonemic response during their initial period of starvation. Whereas normal fasted controls achieved plasma ketone body levels of 727 ± 81 µmol/ liter, the burn patients responded with an average level of 385 ± 77 µmol/liter (p < 0.01). (Journal of Parenteral and Enteral Nutrition 9:153-158, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 2, 153-158 (1985)
DOI: 10.1177/0148607185009002153
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