This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gilsdorf, R.B. Articles by Tillach, P. Search for Related Content PubMed PubMed Citation Articles by Gilsdorf, R.B. Articles by Tillach, P. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Systemic Appearance of Nutrients Placed into the Peritoneal Cavity

Phoenix Nutritional Support Group, Veterans Administration Medical Center, Phoenix, Arizona

R. Selby, M.D.

Phoenix Integrated Surgical Residency, Veterans Administration Medical Center, Phoenix, Arizona

Peter Tillach

Phoenix Nutritional Support Group, Veterans Administration Medical Center, Phoenix, Arizona, Phoenix Integrated Surgical Residency, Veterans Administration Medical Center, Phoenix, Arizona

The use of the peritoneal cavity as a route for delivery of nutrients in patients on continuous ambulatory peritoneal dialysis as well as patients not in renal failure has been proposed. In earlier studies we found dogs could be maintained for 30 days through continuous peritoneal infusion of a solution of amino acids, glucose, and lipids. We then conducted experiments to observe the rate of absorption of nutrients from the gut compared to the peritoneal cavity, the relative rate of absorption of amino acids, sugars, and fats, and the absorption of glucose polymers from the peritoneal cavity. These latter experiments are the subject of this report. In a dog model we observed D-xylose was more rapidly absorbed through the peritoneal cavity than through the gut, but amino acids were absorbed at the same rate. Glucose and amino acid are absorbed at the same rate through the peritoneal cavity, but lipids do not appear in the system circulation for 2 hr. Intraperitoneal glucose polymer produces an increase in serum glucose concentration that is lower and more sustained than what occurs after giving an equal amount of plain glucose. It is concluded that the peritoneal cavity rapidly transports glucose, amino acids, and glucose polymers and slowly transports lipids into the systemic circulation. Consideration of this route for delivery of nutritional support seems reasonable, but further studies of appropriate concentrations and rates of delivery will be required. (Journal of Parenteral and Enteral Nutrition 9: 148-152, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 2, 148-152 (1985)
DOI: 10.1177/0148607185009002148


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Bregendahl, L. Liu, J. P. Cant, H. S. Bayley, B. W. McBride, L. P. Milligan, J.-T. Yen, and M. Z. Fan Fractional Protein Synthesis Rates Measured by an Intraperitoneal Injection of a Flooding Dose of L-[ring-2H5]Phenylalanine in Pigs J. Nutr., October 1, 2004; 134(10): 2722 - 2728. [Abstract] [Full Text] [PDF]

				M. Martinez, G. J. Cuskelly, J. Williamson, J. P. Toth, and J. F. Gregory III Vitamin B-6 Deficiency in Rats Reduces Hepatic Serine Hydroxymethyltransferase and Cystathionine {beta}-Synthase Activities and Rates of In Vivo Protein Turnover, Homocysteine Remethylation and Transsulfuration J. Nutr., May 1, 2000; 130(5): 1115 - 1123. [Abstract] [Full Text]

				M.E. Pessa, H.S. Sitren, E.M. Copeland, J.L. Talbert, G. Schmidt, and T.G. Baumgartner Nutritional Support by Intraperitoneal Dialysis in the Rat: Maintenance of Body Weight with Normal Liver and Plasma Chemistries JPEN J Parenter Enteral Nutr, January 1, 1988; 12(1): 63 - 67. [Abstract] [PDF]