This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Iapichino, G. Articles by Ferro, A. Search for Related Content PubMed PubMed Citation Articles by Iapichino, G. Articles by Ferro, A. Social Bookmarking                         What's this?

Influence of Total Parenteral Nutrition on Protein Metabolism following Acute Injury: Assessment by Urinary 3-Methylhistidine Excretion and Nitrogen Balance

Rianimazione "E. Vecla, " Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, and Istituto di Anestesiologia e Rianimazione, Università degli Studi, Milano

Danilo Radrizzani

Rianimazione "E. Vecla, " Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, and Istituto di Anestesiologia e Rianimazione, Università degli Studi, Milano

Maurizio Solca

Rianimazione "E. Vecla, " Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, and Istituto di Anestesiologia e Rianimazione, Università degli Studi, Milano

Giovanni Bonetti

Servizio di Ricerche Cliniche e Batteriologiche, Ospedale Regina Margherita, Torino

Luisa Leoni

Istituto di Igiene, Università degli Studi, Milano, Italy

Antonella Ferro

Rianimazione "E. Vecla, " Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, and Istituto di Anestesiologia e Rianimazione, Università degli Studi, Milano

The use of total parenteral nutrition after acute injury, either surgical or accidental, is widely accepted for its important benefits, although it is not yet completely understood whether a reduction of body protein catabolism can be effectively achieved. We applied total parenteral nutrition to 14 critically ill patients after either trauma or major surgery. Their daily nitrogen balance, urinary 3-methylhistidine and creatinine excretion, and molar 3-methylhistidine/creatinine ratio, during initial 24-hr fasting period, were respectively -0.19 ± 0.01 (SEM) g kg^-1, 5.46 ± 0.47 µmol kg^-1, 27 ± 4 mg kg^-1, and 0.030 ± 0.005. Daily nonprotein calorie intake of 31.11 ± 0.58 kcal kg^-1, as glucose, and administration of nitrogen 0.350 ± 0.004 g kg^-1, as 10% cristalline L-aminoacids solution, and insulin 1 IU every 5.03 ± 0.14 g of glucose, resulted in progressive decline of urinary 3-methylhistidine (4.21 ± 0.43 µmol kg^-1, p < 0.001), creatinine (22 ± 2 mg kg^-1, NS), and their molar ratio (0.022 ± 0.002, NS). Mean nitrogen balance resulted in 0.032 ± 0.008 g kg^-1. Since urinary 3-methylhistidine role as a marker of protein catabolism is well established, its decrease under total parenteral nutrition together with greatly improved nitrogen balance, demonstrates that our treatment can effectively quench protein catabolism, meanwhile enhancing protein synthesis. (Journal of Parenteral and Enteral Nutrition 9:42-46, 1985)

Journal of Parenteral and Enteral Nutrition, Vol. 9, No. 1, 42-46 (1985)
DOI: 10.1177/014860718500900142


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A.P.C.P. Carlotti, D. Bohn, A.K. Matsuno, D.M. Pasti, M. Gowrishankar, and M.L. Halperin Indicators of lean body mass catabolism: emphasis on the creatinine excretion rate QJM, March 1, 2008; 101(3): 197 - 205. [Abstract] [Full Text] [PDF]

				F.J. Jimenez Jimenez, C. Ortiz Leyba, S. Morales Mendez, M. Barros Perez, and J. Munoz Garcia Prospective Study on the Efficacy of Branched-Chain Amino Acids in Septic Patients JPEN J Parenter Enteral Nutr, May 1, 1991; 15(3): 252 - 261. [Abstract] [PDF]

				C. B. Geibig, J. PontingG Owens, J. M. Mirtallo, D. Bowers, M. Nahikian-Nelms, and P. Tutschka Parenteral Nutrition for Marrow Transplant Recipients: Evaluation of an Increased Nitrogen Dose JPEN J Parenter Enteral Nutr, March 1, 1991; 15(2): 184 - 188. [Abstract] [PDF]

				I. Kawamura, K. Yamazaki, H. Tsuchiya, Y. Miyazawa, K. Isono, T. Akiyama, H. Higashino, and M. Okamoto Optimum Branched-Chain Amino Acids Concentration for Improving Protein Catabolism in Severely Stressed Rats JPEN J Parenter Enteral Nutr, July 1, 1990; 14(4): 398 - 403. [Abstract] [PDF]

				G. Iapichino, D. Radrizzani, A. Colombo, and G. Ronzoni Carnitine Excretion: A Catabolic Index of Injury JPEN J Parenter Enteral Nutr, January 1, 1988; 12(1): 35 - 36. [Abstract] [PDF]

				P. Bouletreau, M.C. Patricot, F. Saudin, M. Guiraud, and B. Mathian Effects of Intermittent Electrical Stimulations on Muscle Catabolism in Intensive Care Patients JPEN J Parenter Enteral Nutr, November 1, 1987; 11(6): 552 - 555. [Abstract] [PDF]