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Carnitine Balance and Effects of Intravenous L-Carnitine in Two Patients Receiving Long-Term Total Parenteral Nutrition

Intensive Care Unit, Royal Adelaide Hospital. Adelaide, and Department of Agricultural Biochemistry, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia

R.C. Fishlock

Intensive Care Unit, Royal Adelaide Hospital. Adelaide, and Department of Agricultural Biochemistry, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia

A.M. Snoswell, PH.D.

Intensive Care Unit, Royal Adelaide Hospital. Adelaide, and Department of Agricultural Biochemistry, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia

Two patients requiring total parenteral nutrition for 34 and 39 months, had plasma and urinary carnitine assays and plasma lipid assays performed before and during intravenous administration of 400 mg (2500 µmol) of L-carnitine for 7 days, followed by 40 mg (240 µmol) daily continuously. One patient had generalized lethargy and weakness which resolved within the first 5 days of carnitine administration. The plasma-free carnitine levels in this patient rose significantly. The other patient was asymptomatic and while there was no significant change in the plasma-free carnitine levels during carnitine administration, this patient remained in positive carnitine balance throughout the study. There were no significant changes in plasma lipid levels in either patient. In adult patients requiring long-term total parenteral nutrition who are otherwise normal, intravenous L-carnitine may be required to supplement the patients endogenous carnitine production. (Journal of Parenteral and Enteral Nutrition 8 :717-719,1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 6, 717-719 (1984)
DOI: 10.1177/0148607184008006717


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