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Journal of Parenteral and Enteral Nutrition
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Prophylaxis and Treatment of Childhood Rickets with Parenteral Cholecalciferol

Joseph S. Bertino, JR, PHARM.D.

Departments of Pharmacy Services and Pediatrics, The Division of Pediatric Pharmacology and Critical Care, Case Western Reserve University, School of Medicine, Cleveland, Ohio, Division of Pediatric Gastroenterology, Case Western Reserve University, School of Medicine, Cleveland, Ohio

Michael D. Reed, PHARM.D.

Departments of Pharmacy Services and Pediatrics, The Division of Pediatric Pharmacology and Critical Care, Division of Pediatric Gastroenterology, Case Western Reserve University, School of Medicine, Cleveland, Ohio

Thomas C. Halpin, JR, M.D.

Rainbow Babies and Children's Hospital, Case Western Reserve University, School of Medicine, Cleveland, Ohio

The safety and efficacy of parenteral cholecalciferol was evaluated in the treatment and prevention of childhood rickets. Children with active disease, and those at high risk for developing rickets were treated either with intravenous or intramuscular cholecalciferol in dosages of 1000 to 1500 IU daily, for periods of 28 to 450 days. All children with rickets responded with radiographic evidence of healing. No child in the prophylaxis group developed bone disease. Side effects were minimal. Parenteral cholecalciferol is a safe and effective therapy for the treatment and prevention of childhood rickets. (Journal of Parenteral and Enteral Nutrition 8:556-559, 1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 5, 556-559 (1984)
DOI: 10.1177/0148607184008005556
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