This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sandstedt, S. Articles by Symreng, T. Search for Related Content PubMed PubMed Citation Articles by Sandstedt, S. Articles by Symreng, T. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Nutrition for Seniors Social Bookmarking                         What's this?

Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response

Department of Anesthesiology, University Hospital, Linkoping, Sweden

Gitten Cederblad

Department of Clinical Chemistry, University Hospital, Linkoping, Sweden

Jörgen Larsson

Department of Surgery, University Hospital, Linkoping, Sweden

Bo Schildt

Department of Anesthesiology, University Hospital, Linkoping, Sweden

Tommy Symreng

Department of Anesthesiology, University Hospital, Linkoping, Sweden

Plasma fibronectin, which is an ₂-glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2-wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3-wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute-phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well-nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short-term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000-000, 1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 5, 493-496 (1984)
DOI: 10.1177/0148607184008005493


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. Holownia, D. J. Newman, H. Thakkar, W. D. Bedzyk, H. Crane, Y. Olabiran, C. L. Davey, and C. P. Price Development and validation of an automated latex-enhanced immunoassay for prealbumin Clin. Chem., June 1, 1998; 44(6): 1316 - 1324. [Abstract] [Full Text] [PDF]

				G. A. Young, C. Chem, M. R. Zeiderman, M. Thompson, and M. J. Mcmahon Influence of Preoperative Intravenous Nutrition upon Hepatic Protein Synthesis and Plasma Proteins and Amino Acids JPEN J Parenter Enteral Nutr, November 1, 1989; 13(6): 596 - 602. [Abstract] [PDF]