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Journal of Parenteral and Enteral Nutrition
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Restoring Patency of Thrombosed Catheters with Cryopreserved Urokinase

Gordon B. Gale, M.D.

Department of Pediatrics, Cardinal Glennon Memorial Hospital for Children/St. Louis University School of Medicine, St. Louis, Missouri

Dennis M. O'Connor, M.D.

Department of Pediatrics, Cardinal Glennon Memorial Hospital for Children/St. Louis University School of Medicine, St. Louis, Missouri

Jen-Yih Chu, M.D.

Department of Pediatrics, Cardinal Glennon Memorial Hospital for Children/St. Louis University School of Medicine, St. Louis, Missouri

Darwin Stanley, R.PH.

Department of Pediatrics, Cardinal Glennon Memorial Hospital for Children/St. Louis University School of Medicine, St. Louis, Missouri

In order to eliminate wasting vials of urokinase, 5000 U/ml aliquots were reconstituted and frozen. The urokinase remained effective for clearing thrombosed catheters for as long as 9 months. When catheters become occluded, patency can be restored by previously frozen urokinase. (Journal of Parenteral and Enteral Nutrition 8:298-299, 1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 3, 298-299 (1984)
DOI: 10.1177/0148607184008003298
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Home page
 JPEN J Parenter Enteral NutrHome page
C. A. Monturo, R. N. Dickerson, and J. L. Mullen
Efficacy of Thrombolytic Therapy for Occlusion of Long-Term Catheters
JPEN J Parenter Enteral Nutr, May 1, 1990; 14(3): 312 - 314.
[Abstract] [PDF]