This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kurkus, J. Articles by Shils, M. E. Search for Related Content PubMed PubMed Citation Articles by Kurkus, J. Articles by Shils, M. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB MANGANESE COMPOUNDS MANGANESE, ELEMENTAL Social Bookmarking                         What's this?

Manganese Content of Large-Volume Parenteral Solutions and of Nutrient Additives

Departments of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, New York

Nancy W. Alcock, PH.D.

Departments of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, New York

Maurice E. Shils, M.D., Sc.D.

Departments of Medicine, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, New York

Manganese (Mn) was analyzed by flameless atomic absorption spectrophotometry in a variety of commercially produced solutions and additives commonly used in total parenteral nutrition (TPN). The amount of Mn in preparations tested varied among manufacturers and among lots. It was generally present in very small amounts with amino acid preparations supplying the major portion in the TPN formulas. Among amino acid solutions, Aminosyn 10% had the highest Mn content (5.2-17.0 µg/liter) with Veinamine 8%, FreAmine II, 8.5%, Travasol 10%, and Nephramine having less than 6.7 µg/liter. Other large volume parenterals contained appreciably less Mn, eg, Dextrose 50% had 0.64-2.5 µg/liter. Some of the additives were high in Mn, eg, potassium phosphate—280 µg/ liter, magnesium sulfate 50%—up to 225 µg/liter, and Berocca C—245.8 µg/liter but their actual contributions to daily TPN intake was no more than 3.3 µg. The calculated Mn content in TPN formulas with varying source materials ranged from 8.07-21.75 µg per total daily volume. These values agreed with those obtained from analysis of actual TPN solutions. The values for 10% Intralipid and 20% Liposyn were 0.5 and 3.0 µg/liter, respectively. (Journal of Parenteral and Enteral Nutrition 8:254-257, 1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 3, 254-257 (1984)
DOI: 10.1177/0148607184008003254


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				N. B. McMillan, C. Mulroy, M. W. MacKay, C. M. McDonald, and W. D. Jackson Correlation of Cholestasis With Serum Copper and Whole-Blood Manganese Levels in Pediatric Patients Nutr Clin Pract, April 1, 2008; 23(2): 161 - 165. [Abstract] [Full Text] [PDF]

				American Society for Parenteral and Enteral Nutrit Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients JPEN J Parenter Enteral Nutr, January 1, 2002; 26(1_suppl): 1SA - 138SA. [PDF]

				D. Boggio Bertinet, M. Tinivella, F. Alessandro Balzola, A. de Francesco, O. Davini, L. Rizzo, P. Massarenti, M. Antonietta Leonardi, and F. Balzola Brain Manganese Deposition and Blood Levels in Patients Undergoing Home Parenteral Nutrition JPEN J Parenter Enteral Nutr, July 1, 2000; 24(4): 223 - 227. [Abstract] [PDF]

				K. Fitzgerald, V. Mikalunas, H. Rubin, R. McCarthy, A. Vanagunas, and R. M. Craig Hypermanganesemia in Patients Receiving Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, November 1, 1999; 23(6): 333 - 336. [Abstract] [PDF]

				C. A. Wardle, A. Forbes, N. B. Roberts, A.V. Jawhari, and A. Shenkin Hypermanganesemia in Long-Term Intravenous Nutrition and Chronic Liver Disease JPEN J Parenter Enteral Nutr, November 1, 1999; 23(6): 350 - 355. [Abstract] [PDF]

				M. M. Pluhator-Murton, R. N. Fedorak, R. J. Audette, B. J. Marriage, R. W. Yatscoff, and L. M. Gramlich Trace Element Contamination of Total Parenteral Nutrition. 1. Contribution of Component Solutions JPEN J Parenter Enteral Nutr, July 1, 1999; 23(4): 222 - 227. [Abstract] [PDF]

				M. M. Pluhator-Murton, R. N. Fedorak, R. J. Audette, B. J. Marriage, R. W. Yatscoff, and L. M. Gramlich Trace Element Contamination of Total Parenteral Nutrition. 2. Effect of Storage Duration and Temperature JPEN J Parenter Enteral Nutr, July 1, 1999; 23(4): 228 - 232. [Abstract] [PDF]

				G. Alves, J. Thiebot, A. Tracqui, T. Delangre, C. Guedon, and E. Lerebours Neurologic Disorders Due to Brain Manganese Deposition in a Jaundiced Patient Receiving Long-Term Parenteral Nutrition JPEN J Parenter Enteral Nutr, January 1, 1997; 21(1): 41 - 45. [Abstract] [PDF]

				E. A. Malecki, H.-C. Lo, H. Yang, C. D. Davis, D. M. Ney, and J.L. Greger Tissue Manganese Concentrations and Antioxidant Enzyme Activities in Rats Given Total Parenteral Nutrition With and Without Supplemental Manganese JPEN J Parenter Enteral Nutr, May 1, 1995; 19(3): 222 - 226. [Abstract] [PDF]

				R. Mehta and J. J. Reilly Manganese Levels in a Jaundiced Long-Term Total Parenteral Nutrition Patient: Potentiation of Haloperidol Toxicity?: Case Report and Literature Review JPEN J Parenter Enteral Nutr, July 1, 1990; 14(4): 428 - 430. [Abstract] [PDF]

				K. M. Hambidge, R. J. Sokol, S. J. Fidanza, and M. A. Goodall Plasma Manganese Concentrations in Infants and Children Receiving Parenteral Nutrition JPEN J Parenter Enteral Nutr, March 1, 1989; 13(2): 168 - 171. [Abstract] [PDF]