This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Howard, L. Articles by Cho, E. Search for Related Content PubMed PubMed Citation Articles by Howard, L. Articles by Cho, E. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Decreased Plasma Fibronectin during Starvation in Man

Departments of Physiology and Medicine, Neil Hellman Medical Research Building, Albany Medical College of Union University, Albany, New York

Bruce Dillon

Departments of Physiology and Medicine, Neil Hellman Medical Research Building, Albany Medical College of Union University, Albany, New York

Thomas M. Saba

Departments of Physiology and Medicine, Neil Hellman Medical Research Building, Albany Medical College of Union University, Albany, New York

Susan Hofmann

Departments of Physiology and Medicine, Neil Hellman Medical Research Building, Albany Medical College of Union University, Albany, New York

Eshin Cho

Departments of Physiology and Medicine, Neil Hellman Medical Research Building, Albany Medical College of Union University, Albany, New York

This study evaluated the effect of 5 days of starvation followed by 5 days of refeeding on immunoreactive plasma and serum fibronectin and associated opsonic activity as studied by peritoneal macrophage monolayer bioassay in 12 healthy women volunteers. The temporal alteration of fibronectin was compared with the serum albumin, total iron-binding capacity, and retinol-binding protein levels. Fibronectin concentration and opsonic activity were also determined in two cachectic patients who were 61 and 78% of their ideal body weight. Prior to starvation, plasma fibronectin was 292 ± 20 µg/ml and serum fibronectin was 182 ± 16 in all subjects. After 5 days of starvation, immunoreactive fibronectin decreased (p < 0.05) by 20-25%. This decrease was not great enough to impair opsonic activity as tested by the in vitro macrophage assay. Starvation caused no decrease in serum albumin or total iron-binding capacity, although retinol-binding protein decreased by 35%. During refeeding, subjects were randomized to a diet with (n = 6) and without (n = 6) carbohydrate. After 5 days of refeeding, fibronectin levels were normalized on the carbohydrate-containing diet, but were still low (82% of normal) on the carbohydrate-free diet. Retinol-binding protein did not fully normalize after 5 days of refeeding. In the two cachectic patients, fibronectin levels prior to total parenteral nutrition were 25 and 75% of normal. Thus, starvation can lower fibronectin levels and this protein is rapidly restored with adequate nutrition. (Journal of Parenteral and Enteral Nutrition 8:237-244, 1984)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 3, 237-244 (1984)
DOI: 10.1177/0148607184008003237


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. C. Heimburger, W. J. Geels, J. Bilbrey, D. T. Redden, and C. Keeney Effects of Small-Peptide and Whole-Protein Enteral Feedings on Serum Proteins and Diarrhea in Critically III Patients: A Randomized Trial JPEN J Parenter Enteral Nutr, May 1, 1997; 21(3): 162 - 167. [Abstract] [PDF]

				G. A. Young, C. Chem, M. R. Zeiderman, M. Thompson, and M. J. Mcmahon Influence of Preoperative Intravenous Nutrition upon Hepatic Protein Synthesis and Plasma Proteins and Amino Acids JPEN J Parenter Enteral Nutr, November 1, 1989; 13(6): 596 - 602. [Abstract] [PDF]

				D. F. Kirby, R. J. Marder, R. M. Craig, R. Eskildsen, and P. Middaugh The Clinical Evaluation of Plasma Fibronectin as a Marker for Nutritional Depletion and Repletion and as a Measure of Nitrogen Balance JPEN J Parenter Enteral Nutr, November 1, 1985; 9(6): 705 - 708. [Abstract] [PDF]

				G. D. Horowitz, J. S. Groeger, A. Legaspi, and S. F. Lowry The Response of Fibronectin to Differing Parenteral Caloric Sources in Normal Man JPEN J Parenter Enteral Nutr, July 1, 1985; 9(4): 435 - 438. [Abstract] [PDF]