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Improved N-retention during L-Carnitine-Supplemented Total Parenteral Nutrition

Uniuersity Children's Hospital

H. Segerer, M.D.

Uniuersity Children's Hospital

W. Fekl, PH.D.

Institute for Experimental Nutrition, Erlangen, Federal Republic of Germany

The influence of intravenously administered L-carnitine on lipid- and nitrogen-metabolism was studied during total parenteral nutrition of piglets (mean weight 4077 g; n = 9). The infusion protocol was divided into three isocaloric and isonitrogenous 48-hr periods. Amino acids (3 g/kg day) were administered throughout all three periods: 140 cal/kg/day were given as nonprotein calories, consisting only of glucose during period 1; during periods 2 and 3, an amount of glucose calorically equivalent to 4 g fat/kg/day was substituted with a lipid emulsion, and L-carnitine (1.5 mg/kg/day) was added in period 3. Key parameters of fat- and nitrogen-metabolism were determined during the entire regime. Indirect calorimetry was performed and the respiratory quotient calculated during all three periods. The results demonstrate a more effective lipolysis and oxydation of fatty acids during L-carnitine supplementation. These changes produce an increased energy gain from exogenously administered fat and a distinct improvement in nitrogen balance. (Journal of Parenteral and Enteral Nutrition 8:9-13, 1983)

Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 1, 9-13 (1984)
DOI: 10.1177/014860718400800109


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