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Journal of Parenteral and Enteral Nutrition
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Vitamin C Supplementation of Total Parenteral Nutrition Formulas

Vasken Abrahamian, PH.D.

Research, Midwest Nutrition, Education and Research Foundation

Mitchell V. Kaminski, JR., M.D., F.A.C.S.

Division of Surgical Nutrition, University of Health Sciences/The Chicago Medical School, Midwest Nutrition, Education and Research Foundation

Gustavo Cruz Santiago, M.D.

Hospital General, Instituto Mexicano del Seguro Social, Mexico City, Mexico

The effect of a wide range of daily vitamin C intake (350-2250 mg, mean 975 mg) on the serum and urine vitamin C levels was studied in 20 adult hospitalized patients receiving total parenteral nutrition for a period greater than 15 days. Serum vitamin C levels increased with vitamin C administration, but remained within the normal range. Urine vitamin C levels were above normal during total parenteral nutrition in all but one patient. A positive vitamin C "balance" was achieved in all patients. The vitamin C intake positively correlated with the vitamin C urine concentration and vitamin C "balance." Maximal vitamin C retention was 800 mg/day. It is concluded that administration of vitamin C in doses greater than 1000 mg/day is unjustified in those patients receiving total parenteral nutrition who are not hypermetabolic. (Journal of Parenteral Nutrition 7:465-469, 1983)

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 5, 465-469 (1983)
DOI: 10.1177/0148607183007005465
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[Abstract] [PDF]