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Iron Supplementation of Total Parenteral Nutrition: A Prospective Study

Metabolism Section, Surgery Branch, National Cancer Institute and the Biometric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

M.L. Peters, M.D.

Metabolism Section, Surgery Branch, National Cancer Institute and the Biometric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

R. Wesley, PH.D.

Metabolism Section, Surgery Branch, National Cancer Institute and the Biometric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

M.M. Maher, R.N.

Metabolism Section, Surgery Branch, National Cancer Institute and the Biometric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

M.F. Brennan, M.D.

Metabolism Section, Surgery Branch, National Cancer Institute and the Biometric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 1275 York Avenue, New York, NY 10021

A prospective study to evaluate the iron dosage needed to restore serum iron levels was performed on patients receiving prolonged total parenteral nutrition (TPN). Intravenous iron intakes of 0, 25, 87.5, and 175 mg/wk were sequentially studied. No untoward responses were seen in 42 patients studied for 2758 patient days. When compared to pre-TPN levels, serum iron levels increased significantly with increasing iron dosage (p < 0.002). In every single patient at the two highest dosage levels, serum iron levels at 3 wk rose from the pre-TPN level. Hemoglobin, reticulocyte count, transfusion requirement, total iron binding capacity, and red cell indices were not affected by iron dosage. There was no increased incidence of sepsis in patients who received increasing iron dosage. Both the 87.5 and 175 mg/wk iron doses increased serum iron levels from pre-TPN values, but the highest dose increased serum iron levels above the normal range in 80% of patients after 3 wk of administration allowing us to recommend the 87.5 mg/wk dose. (Journal of Parenteral and Enteral Nutrition 7:457-461, 1983)

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 5, 457-461 (1983)
DOI: 10.1177/0148607183007005457


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