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Journal of Parenteral and Enteral Nutrition
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Nutritional Efficacy and Hepatic Changes during Intragastric, Intravenous, and Prehepatic Feeding in Rats

Walter W.-K. King, M.D.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Roelof U. Boelhouwer, M.D.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Andrew N. Kingsnorth, M.B., F.R.C.S.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Jeffrey S. Ross, M.D.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Vernon R. Young, PH.D.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

Ronald A. Malt, M.D.

Surgical Services, Shriners Burns Institute and Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

The nutritional efficacy and hepatic changes in rats given a total parenteral nutrition (TPN) solution consisting of 4.25% amino acids and 25% dextrose by intragastric, intravenous, or prehepatic routes were studied over a 4-day period. Rats fed Purina Chow or given intragastric TPN maintained body weight and showed no appreciable fatty change of liver. In contrast, weight loss, hepatomegaly, and a 37% increase in liver lipid content were observed in rats given intravenous TPN and a 60% increase after prehepatic TPN. Approximately half the rats given intravenous or prehepatic TPN developed fatty changes in the liver. Serum albumin concentration and hepatic protein content were not improved after prehepatic TPN. Serum SGOT and SGPT were elevated in rats given prehepatic TPN only. Prehepatic TPN may result in hepatic injury and offers no apparent benefit over conventional intravenous TPN in rats. (Journal of Parenteral and Enteral Nutrition 7: 443-446, 1983)

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 5, 443-446 (1983)
DOI: 10.1177/0148607183007005443
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