Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Parenteral and Enteral Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Torosian, M. H.
Right arrow Articles by Buzby, G. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Torosian, M. H.
Right arrow Articles by Buzby, G. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Enhanced Tumor Response to Cycle-Specific Chemotherapy by Parenteral Amino Acid Administration

Michael H. Torosian, M.D.

Surgery, Department of Surgery and Clinical Nutrition Center, University of Pennsylvania School of Medicine

James L. Mullen, M.D.

Surgery, Department of Surgery and Clinical Nutrition Center, University of Pennsylvania School of Medicine

Elizabeth E. Miller, PH.D.

Harrison Department of Surgical Research, University of Pennsylvania School of Medicine

Kendall R. Zinsser, M.D.

Department of Pathology, Good Samaritan Hospital, Lebanon, Pa

T. Peter Stein, PH.D.

Surgery, University of Pennsylvania School of Medicine

Gordon P. Buzby, M.D.

Surgery, Department of Surgery and Clinical Nutrition Center, University of Pennsylvania School of Medicine

Forced feeding has been shown to effectively stimulate tumor metabolism in numerous animal models. Significant acceleration of tumor growth by exogenous nutrient administration is generally considered to be detrimental to the host. The present study was performed to determine if substrate-induced alterations in tumor metabolism could be exploited to enhance tumor response to cycle-specific chemotherapy. Following subcutaneous mammary tumor implantation (AC-33) and protein depletion, 39 female Lewis/Wistar rats were randomly assigned to one of four nutritional regimens for 48 hr: (1) protein-depleted food (0.03% protein) ad libitum po, (2) parenteral carbohydrate (18.6% dextrose), (3) parenteral amino acids (2.8% amino acids), or (4) total parenteral nutrition (18.6% dextrose/2.8% amino acids). Methotrexate (5 mg/kg im) was administered to all animals 2 hr after initiating these nutritional regimens. Tumor volume and host toxicity were monitored throughout the study. At sacrifice, significant reduction in tumor volume was observed in animals receiving parenteral amino acids (0.37 ± 0.24 cm3) and total parenteral nutrition (0.25 ± 0.18 cm3) compared to the group receiving protein-depleted food po (0.70 ± 0.22 cm3) (p < 0.01). In this animal model, the parenteral administration of amino acids with or without the addition of hypertonic dextrose was found to effectively potentiate tumor response to methotrexate without increasing host toxicity. (Journal of Parenteral and Enteral Nutrition 7:337-345, 1983)

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 4, 337-345 (1983)
DOI: 10.1177/0148607183007004337
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
D. Jin, M. Phillips, and J. E. Byles
Effects of Parenteral Nutrition Support and Chemotherapy on the Phasic Composition of Tumor Cells in Gastrointestinal Cancer
JPEN J Parenter Enteral Nutr, July 1, 1999; 23(4): 237 - 241.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
M. H. Torosian
Stimulation of Tumor Growth by Nutrition Support
JPEN J Parenter Enteral Nutr, November 1, 1992; 16(6_suppl): 72S - 75S.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
F. Rossi-Fanelli, A. Cascino, and M. Muscaritoli
Review: Abnormal Substrate Metabolism and Nutritional Strategies in Cancer Management
JPEN J Parenter Enteral Nutr, November 1, 1991; 15(6): 680 - 683.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
T. J. Miller, R. S. Franco, W. T. Chance, O. J. Martelo, and M. B. Popp
Amino Acid Requirements of a Rat Sarcoma as Determined by a Stem Cell Assay
JPEN J Parenter Enteral Nutr, May 1, 1987; 11(3): 223 - 228.
[Abstract] [PDF]