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Journal of Parenteral and Enteral Nutrition
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Comparative Study of Clearance of 10% and 20% Fat Emulsion

Mitchell V. Kaminski, JR., M.D., F.A.C.S.

Department of Surgery and Division of Surgical Nutrition, University of Health Sciences/The Chicago Medical School, Chicago, Illinois, Metabolic Support Service, Thorek Hospital and Medical Center, Chicago, Illinois, Midwest Nutrition, Education and Research Foundation, Chicago, Illinois

Vasken Abrahamian, PH.D.

Midwest Nutrition, Education and Research Foundation, Chicago, Illinois

Sonia A. Chrysomilides, M.S.

Midwest Nutrition, Education and Research Foundation, Chicago, Illinois

Norma J. Nasr, M.S., R.D.

Midwest Nutrition, Education and Research Foundation, Chicago, Illinois

Michael K. Armstrong, PH.D.

Midwest Nutrition, Education and Research Foundation, Chicago, Illinois

Don M. Lynch, PH.D.

Abbott Laboratories, North Chicago, Illinois

The rate of fat emulsion clearance from the blood of 10 healthy adult male volunteers administered 0.1 gram of fat per kilogram body weight as 10% or 20% safflower oil emulsion (Liposyn) was studied. The subjects were hospitalized for 2 days and each was given the predetermined amount of one of the two fat emulsions (10% or 20%) by rapid injection into a peripheral vein and the rate of clearance of the emulsion determined over a 60-minute period, beginning when half of the emulsion had been injected. There was no significant difference in the clearance rate between the two emulsions. It is concluded that 20% fat emulsion is as safe as 10% fat emulsion for use in intravenous nutritional support.

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 2, 126-130 (1983)
DOI: 10.1177/0148607183007002126
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Home page
 Nutr Clin PractHome page
M. Roesner and J. P. Grant
Invited Review: Intravenous Lipid Emulsions
Nutr Clin Pract, June 1, 1987; 2(3): 96 - 107.
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