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Journal of Parenteral and Enteral Nutrition
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Supplementation of Total Parenteral Nutrition Solutions with Ferrous Citrate

Merlin H. Sayers, M.B., B.CH., PH.D.

Division of Hematology. University Hospital, University of Washington, Seattle, Washington

David K. Johnson, PH.D.

Louis A. Schumann, R.PH., M.S.

Department of Pharmacy Services. University Hospital, University of Washington, Seattle, Washington

Marianne F. Ivey, R.PH.

Division of Nephrology. University Hospital, University of Washington, Seattle, Washington

Jeffry H. Young, M.D.

Division of Nephrology. University Hospital, University of Washington, Seattle, Washington

Clement A. Finch, M.D.

Division of Hematology. University Hospital, University of Washington, Seattle, Washington

Daily infusion of a total parenteral nutrition (TPN) formulation containing 1 liter of 5.5% Travasol provides less than 0.1 milligrams of iron. By comparison, a formulation which includes a liter of 10% Travamin provides 2 milligrams of iron per day. To meet iron requirements in patients infusing formulations containing Travasol, iron was added as ferrous citrate. In in vitro experiments, 74% of this iron was available to transferrin. In seven patients in whom in vivo availability was tested by red cell incorporation, the mean availability was 81%. Ferrous citrate is recommended as a safe, effective additive to TPN solutions for adult patients requiring iron supplements.

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 2, 117-120 (1983)
DOI: 10.1177/0148607183007002117
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