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Journal of Parenteral and Enteral Nutrition
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Hemoglobin A1C in Home Parenteral Nutrition

Jay M. Mirtallo, M.S., R.Ph.

Department of Pharmacy, College of Pharmacy, and the College of Medicine, The Ohio State University, Columbus, Ohio

Peter J. Fabri, M.D.

Department of Pharmacy, College of Pharmacy, and the College of Medicine, The Ohio State University, Columbus, Ohio

Hemoglobin A1C or glycosylated hemoglobin has been described as being effective in monitoring long-term glucose control in diabetics. The usefulness of HbA1C in reflecting glucose homeostasis during chronic hypertonic dextrose infusions in 6 patients receiving cyclic home TPN was studied at monthly intervals. Grouped data for the 34 values representing study periods of 5 to 10 months averaged 7.5 ± 0.2% (Mean ± SEM) indicating that HbA1C levels were not elevated above normal (4-8%) in these patients while receiving a dextrose based diet. Final values of HbA 1C (7.3 ± 0.4%, mean ± SEM) although lower than early values (8.7 ± 0.6%, mean ± SEM) were not significantly different ( p > 0.05, Student's paired t-test). The change in HbA1C that occurred in these patients probably reflects the response to an altered glucose load infused by the patient.

HbA1C is a convenient and apparently accurate method of evaluating chronic glucose tolerance in patients receiving home TPN and may be used as an alternate method for monitoring glucose tolerance on an outpatient basis.

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 1, 59-61 (1983)
DOI: 10.1177/014860718300700159
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