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Journal of Parenteral and Enteral Nutrition
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Limited Value of Nephelometry in Monitoring the Administration of Intravenous Fat in Neonates

Arthur D'Harlingue, M.D.

Divisions of Neonatology and Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

Andrew O. Hopper, M.D.

Divisions of Neonatology and Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

David K. Stevenson, M.D.

Divisions of Neonatology and Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

Susan M. Shahin, B.S.

Divisions of Neonatology and Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

John A. Kerner, JR., M.D.

Divisions of Neonatology and Gastroenterology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California

To evaluate the usefulness of nephelometry in predicting hyperlipidemia in neonates receiving intravenous fat (IVF), 23 infants in our neonatal intensive care nursery had simultaneous measurements of the serum IVF level (as determined by nephelometry), triglyceride, cholesterol, and free fatty acid/albumin molar ratio. There was a positive correlation between the serum IVF level and triglycerides, but the IVF level did not reliably predict elevated triglycerides, cholesterol, or free fatty acid-albumin molar ratio. Thus, neonates receiving IVF emulsions cannot be monitored by nephelometry alone. Adequate monitoring requires measurement of specific lipid fractions.

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 1, 55-58 (1983)
DOI: 10.1177/014860718300700155
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