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Journal of Parenteral and Enteral Nutrition
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Effect of Heparin on Lipoprotein Profile During Parenteral Fat Infusions

A. Benderly

Department of Pediatrics "A"-The Unit for Lipid Research Rambam Medical Center, Haifa, Israel

E. Rosenthal

Department of Pediatrics "A"-The Unit for Lipid Research Rambam Medical Center, Haifa, Israel

J. Levi

Department of Pediatrics "A"-The Unit for Lipid Research Rambam Medical Center, Haifa, Israel

G. Brook

Department of Pediatrics "A"-The Unit for Lipid Research Rambam Medical Center, Haifa, Israel

Long-term administration of Intralipid to infants raises the potential risk of cumulative hyperlipemia. The elimination of lipoproteins from the blood during 3 hours of Intralipid infusion (0.33 grams per kilogram per hour) was investigated in five term infants during two infusion periods without and with heparin. A single intravenous injection of heparin (100 micron per kilogram) preceded the period of Intralipid infusion. During the nonheparin periods levels of triglycerides (L-particles) rose progressively to 1320±133 milligrams per 100 milliliters plasma, whereas during the heparin periods levels rose more moderately and peaked at 636±107 milligrams per 100 milliliter plasma (p <0.001-0.05). The study suggests that the heparin effect is still apparent for a period of 6 hours and repeated bolus injections may keep triglyceride levels at approximately normal concentrations during constant Intralipid infusion (0.166 grams per kilograms per hour).

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 1, 37-39 (1983)
DOI: 10.1177/014860718300700137
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[Abstract] [PDF]