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Delivery of Vitamins A, D, and E in Total Parenteral Nutrition Solutions

Divisions of Clinical Nutrition and Endocrinology, Department of Paediatrics and the Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

Glenville Jones, PH.D.

Divisions of Clinical Nutrition and Endocrinology, Department of Paediatrics and the Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

Paul Pencharz, M.B., PH.D., F.R.C.P. C.

Divisions of Clinical Nutrition and Endocrinology, Department of Paediatrics and the Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

The ward delivery of fat-soluble vitamins in parenteral nutrition solutions was simulated in a laboratory situation. Radioactively labeled vitamins A, D, and E were used in tracer studies to follow their nonradioactive counterparts during addition to a parenteral solution and subsequent passage through a standard infusion set. Using this quick convenient method, it was possible to monitor delivery over an entire 24-hour infusion period. Average recovery for vitamins A, D, and E was 31%, 68% and 64%, respectively. From comparison of various sampling sites during the experimental period, it seems clear that the fat-soluble vitamins appear to adhere to the bag and tubing. In light of these findings, we suggest a reexamination of the method of solubilization of fat soluble vitamins and of the materials used in the manufacture of clinical infusion equipment.

Journal of Parenteral and Enteral Nutrition, Vol. 7, No. 1, 11-14 (1983)
DOI: 10.1177/014860718300700111


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