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Changes in Circadian Rhythmicity of Liver and Serum Parameters in Rats Fed a Total Parenteral Nutrition Solution by Continuous and Discontinuous Intravenous or Intragastric Infusion

Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania, Department of Physiology and Biophysics, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey

Harry S. Sitren, PH.D.

Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania, Department of Physiology and Biophysics, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey

Nancy R. Stevenson, PH.D.

Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania, Department of Physiology and Biophysics, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey

Francis E. Rosato, M.D.

Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania, Department of Physiology and Biophysics, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, Piscataway, New Jersey

Circadian rhythms were assessed in rats (224-246 grams) receiving either an intragastric (IG) or intravenous (IV) infusion continuously (C), or IG or IV infusions discontinuously (D) from 0000 to 1400 hours daily. A control group was maintained on a stock diet ad libitum. IV- and IG-fed rats were infused with 50 milliliters per day of a solution containing 25% dextrose and 4.25% amino acids plus vitamins and minerals. After 10 to 11 days, groups of rats were killed from each treatment every 6 hours over a 24-hour period. Results showed that IG feeding promoted better growth and nitrogen retention than IV feeding. Rhythm patterns for liver weight, glycogen, and protein content were similar between D-IG and D-IV infused rats. All groups except the D-IV fed rats exhibited fluctuations of serum insulin. A rhythm was not present for serum glucose in C-IV fed rats and a rhythm was also absent for serum albumin in both C-IV and D-IV fed rats. C-IV feeding increased serum glucose and insulin levels and decreased serum albumin levels in comparison to IG feeding. In comparison to the ad libitum-fed, control rats, C-IV or D-IV or IG infusions led to alterations in liver and serum parameters.

Journal of Parenteral and Enteral Nutrition, Vol. 6, No. 6, 496-502 (1982)
DOI: 10.1177/0148607182006006496


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