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Journal of Parenteral and Enteral Nutrition
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Effect of Serum Zinc Level on Amount of Collagen-Hydroxyproline in the Healing Gut during Total Parenteral Nutrition: An Experimental Study

Keiji Iriyama, M.D.

Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, 514 Japan

Takao Mori, M.D.

Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, 514 Japan

Takumi Takenaka, M.D.

Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, 514 Japan

Tadashi Teranishi, M.D.

Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, 514 Japan

Hiroshi Mori, M.D.

Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, 514 Japan

Changes of serum zinc level in dogs receiving either a zinc-free solution or a zinc-supplement solution during total parenteral nutrition (TPN) and the influence of variety of serum-zinc level on serum albumin and collagen-hydroxyproline (C-Hyp) in the incised intestine were investigated. The serum zinc level of zinc-free dogs that was 126.0 ± 34.3 micrograms per deciliter at the initiation of TPN decreased significantly to 80.0 ± 15.0 micrograms per deciliter during the one week of TPN, whereas that of zinc-supplement dogs did not decrease during the same period of TPN. Lowering of the serum albumin value was more evident in zinc-free dogs than in zinc-supplement dogs. The amount of C-Hyp in the incised area of the intestine of zinc-free dogs was 2.63 ± 0.66 micrograms per milligram and that of zinc-supplement dogs was 4.26 ± 1.04 micrograms per milligram and this difference was significant. It was found that serum zinc level during TPN sharply reflects a supplement of zinc, and C-Hyp in the incised gut and serum albumin of zinc-free dogs are lower than those of zinc-supplement dogs.

Journal of Parenteral and Enteral Nutrition, Vol. 6, No. 5, 416-420 (1982)
DOI: 10.1177/0148607182006005416


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JPEN J Parenter Enteral NutrHome page
D. K. Heyland, N. Jones, N. Z. Cvijanovich, and H. Wong
Zinc Supplementation in Critically Ill Patients: A Key Pharmaconutrient?
JPEN J Parenter Enteral Nutr, September 1, 2008; 32(5): 509 - 519.
[Abstract] [Full Text] [PDF]