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Journal of Parenteral and Enteral Nutrition
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A Primate Model for Enteral Nutrition by Tube

Lenora R. Barot, M.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

John L. Rombeau, M.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

T. Peter Stein, PH.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

Ronni Chernoff, ED.M., R.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

R.G. Settle, PH.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

James L. Mullen, M.D.

University of Pennsylvania, School of Medicine and Cancer Center, and the Veterans Administration Medical Center, Philadelphia, Pennsylvania

To establish an animal model for the controlled study of enteral nutrition by tube, five adult chair-adapted primates (Macaca fasicularis) had gastrostomy and jejunostomy tubes placed for the delivery of a modified protein isolate diet. Following 7 days of postoperative depletion with a hypo-caloric infusion of dextrose (20 kcal, 0 g N/kg/day), the animals were repleted for 10 days with tube feedings (124 kcal, 0.73 g N/kg/day). There was no operative mortality or morbidity and each animal demonstrated conversion to anabolism by significant weight gain, positive nitrogen balance, and net protein synthesis as determined by [15N]glycine protein turnover rates. Significant correlation was found between caloric intake and nitrogen balance at the level of nitrogen provided in this diet (r = 0.88, p < 0.05). This model was found to be well suited for the surgical and nutritional techniques required for the long-term study of enteral nutrition by tube.

Journal of Parenteral and Enteral Nutrition, Vol. 6, No. 1, 34-38 (1982)
DOI: 10.1177/014860718200600134
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This article has been cited by other articles:


Home page
 JPEN J Parenter Enteral NutrHome page
S. Langaniere and D. Maestracci
A Technique for Enteral Feeding In Unrestrained Chronic Dogs
JPEN J Parenter Enteral Nutr, May 1, 1985; 9(3): 370 - 374.
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