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Serum-Sulfated Lithocholate as an Indicator of Cholestasis During Parenteral Nutrition in Infants and Children

Children's Hospital Research Foundation, Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio

William F. Balistreri, M.D.

Children's Hospital Research Foundation, Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio

Frederick J. Suchy, M.D.

Children's Hospital Research Foundation, Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio

Serum-sulfated lithocholate concentrations were followed in 55 patients receiving parenteral nutrition. Elevation of serum lithocholate occurred in 18 (10/34 under 6 months of age, 8/21 older than 6 months). Serum sulfated lithocholate concentrations were a more sensitive indicator of cholestasis than either direct bilirubin or aminotransferases. The serum lithocholate concentrations in parenteral nutrition-associated liver disease were similar to those seen in patients with known cholestasis.

Journal of Parenteral and Enteral Nutrition, Vol. 6, No. 1, 30-33 (1982)
DOI: 10.1177/014860718200600130


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