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Journal of Parenteral and Enteral Nutrition
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The Effect of Intravenous Doxycycline Hyclate on Total Parenteral Nutrition in Protein Malnourished Rats

C. Douglas Lees, M.D., F.R.C.S. GLAS.

Department of General Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio

Megan O'Neill, B.A.

Department of General Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio

Ezra Steiger, M.D., F.A.C.S.

Department of General Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio

To study the effects of intravenous doxycycline hyclate on protein malnourished rats, 20 male Sprague-Dawley rats, weighing 234 to 277 g, were protein depleted for 6 weeks then randomly assigned to one of two groups: group I ( 10 rats), total parenteral nutrition with intravenous doxycycline hyclate injections, group II (10 rats), total parenteral nutrition with normal saline injections. Both groups were then protein repleted for 7 days. Body weight; fluid intake; urine output; liver, spleen, and lung weights; nitrogen content; and serum proteins were measured. The antibiotic dosage given was 10 mg/kg body weight/day or 0.1688 ± 0.0046 mg/day. There was no significant difference in starting weight, weight after 6 weeks of protein depletion, weight at sacrifice, or weight gain between groups I and II. Average fluid intake/day for groups I (50 ± 2 ml) and II (51 ± 3 ml) were not statistically significant. There was no significant difference in average urine output/day nitrogen balance, liver weight, and liver nitrogen, spleen and lung weights, or serum albumin levels (Group I, 2.84 ± 0.48 g%, Group II, 2.72 ± 0.24 g%). Intravenous doxycycline hyclate does not appear to have a protein catabolic effect on protein malnourished rats receiving total parenteral nutrition.

Journal of Parenteral and Enteral Nutrition, Vol. 5, No. 6, 510-512 (1981)
DOI: 10.1177/0148607181005006510
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