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Vitamin A and E Requirements During Total Parenteral Nutrition

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Akira Yamaji, PH.D.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Kazusaburo Kataoka, M.S.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Yasuko Fuj, B.S.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Keiko Nishikawa, B.S.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Noboru Ohnishi, PH.D.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Echi Hiraoka, PH.D.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Akira Okada, M.D., PH.D.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Chang-Woong Kim, M.D.

Departments of Pharmacy and Surgery, Osaka University Hospital and Medical School, Osaka, Japan

Studies were undertaken to determine rational dosages of vitamins A and E during long-term total parenteral nutrition (TPN). Four kinds of vitamin prescriptions containing different amounts of vitamin A and E were prepared from commercially available products and/or hospital pharmacy products. Patients were divided into four groups according to the vitamin prescription used. Plasma vitamin levels of different patient groups were determined by a modified fluorimetric method and were compared with those of a normal subject group. The stability of vitamin A and E in TPN solution after admixing was determined by measuring the remaining vitamin contents by high pressure liquid chromatography. From the results, it was concluded that 1) about 50% of vitamin A was decomposed by sunlight (about 2000 lux) 3 hr after admixing and an organge-colored vinyl cover could protect its photodecomposition; 2) vitamin E was stable at any condition tested; 3) 2500 IU of vitamin A and 15 IU of vitamin E could meet the daily requirements; 4) the plasma levels of vitamin A and E were correlative (p < 0.01); and 5) concomitant administration of vitamin E was essential to keep the proper level of vitamin A in plasma.

Journal of Parenteral and Enteral Nutrition, Vol. 5, No. 5, 420-423 (1981)
DOI: 10.1177/0148607181005005420


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