This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Shizgal, H. M. Articles by Forse, R. A. Search for Related Content PubMed PubMed Citation Articles by Shizgal, H. M. Articles by Forse, R. A. Social Bookmarking                         What's this?

Total Parenteral Nutrition with Vamin and Intralipid

Department of Surgery, McGill University, Royal Victoria Hospital, Montreal, Canada

R. Armour Forse, M.D.

Department of Surgery, McGill University, Royal Victoria Hospital, Montreal, Canada

The present study was undertaken to evaluate the efficacy of total parenteral nutrition (TPN) with a solution containing 10% fructose and 7% crystalline amino acid (Vamin), administered with equal volumes of a 10% soybean oil emulsion (Intralipid). The two solutions are available in separate sterile containers and therefore solution preparation is not required. Because the 10% Intralipid emulsion is isotonic, a central venous catheter is not required. Patients referred for TPN were randomly allocated to receive either the Vamin and Intralipid combination or a solution containing 2.5% L-amino acids (Travasol) and 25% dextrose. The efficacy of each solution was assessed by determining body composition by multiple isotope dilution, at the onset, at 2-week intervals during, and at the completion of, TPN. In 49 patients receiving Vamin and Intralipid, 109 body composition studies were performed to evaluate 61 periods of TPN of 14.6 ± 0.5 days duration. One hundred and sixty-seven studies were performed in 73 patients receiving TPN with hypertonic dextrose to evaluate 92 periods of TPN of 15.3 ± 0.5 days. In the absence of preexisting malnutrition, both solutions maintained body composition. In the presence of preexisting malnutrition, TPN with the Vamin and Intralipid combination maintained, but did not improve, body composition. However, TPN with the hypertonic dextrose solution resulted in a significant improvement in the nutritional state with an increase in the body cell mass, accompanied by a contraction of the extracellular mass. Conventional TPN with 2.5% crystalline amino acids and hypertonic dextrose was superior to TPN with Vamin and Intralipid.

Journal of Parenteral and Enteral Nutrition, Vol. 5, No. 5, 391-396 (1981)
DOI: 10.1177/0148607181005005391


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Bahrami, W. Strohmaier, H. Redl, and G. Schlag Mechanical Properties of the Lungs of Posttraumatic Rats Are Improved by Including Fat in Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, November 1, 1987; 11(6): 560 - 565. [Abstract] [PDF]