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Vitamin Status During Total Parenteral Nutrition

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

Alan Shenkin, B.Sc., M.B.CH.B., PH.D.

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

Rosalynd A. Campbell, B.Sc., PH.D.

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

Richard J. Spooner, B.Sc.

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

John F. Davidson, F.R.C.P. EDIN., M.R.C.PATH.

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

Andrew J.W. Sim, F.R.C.S.

Departments of Biochemistry, Surgery and Haematology, Royal Infirmary, Glasgow, Scotland

Plasma concentrations of vitamins A and E, serum and erythrocyte folic acid, serum B₁₂ and erythrocyte enzyme activations (to assess vitamins Bi, B2 and B6 status) were measured at the start and finish of 39 courses of total parenteral nutrition (TPN). The daily regimen was standard. Plasma vitamin A, E, and folate concentrations and vitamin B₆ status improved significantly during TPN. Three patients developed low levels of vitamin A and two patients developed high transketolase activations (B ₁ depletion) during therapy. The adequacy of vitamin replacement and the monitoring of vitamin status during TPN is discussed.

Journal of Parenteral and Enteral Nutrition, Vol. 5, No. 4, 295-299 (1981)
DOI: 10.1177/0148607181005004295


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