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Journal of Parenteral and Enteral Nutrition
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Nutritional and Immunological Evaluations in Cancer Patients. Relationship to Surgical Infections

Paolo Dionigi, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Renzo Dionigi, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Stefano Nazari, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Alberto Pietro Bonoldi, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Antonella Griziotti, Biol. D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Franco Pavesi, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Carlo Tibaldeschi, M.D.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Flavio Cividini, B.S.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Ilvo Gratton, B.S.

From the Istituto di Patologia Chirurgica and Istituto di Scienza delta Alimentazione, University of Pavia-Servizio di Analisi Chimico-Cliniche, Policlinico San Matteo, Pavia, Italy

Several reports provide evidence of the synergism between malnutrition and infection in hospitalized patients. In this study, preoperative complete nutritional assessment (NA) was performed to: 1) evaluate NA modifications in 21 controls with benign minor surgical diseases and in 71 surgical cancer patients; 2) determine the relative value of nutritional and immunological indicators in relation to the postoperative septic complications in cancer patients. The following parameters were used: percent ideal body weight, percent usual body weight, percent weight loss/month, percent standard arm circumference, percent standard triceps skinfold; hematocrit, hemoglobin, serum proteins, albumin, iron, transferrin, ceruloplasmin, retinol binding protein (RBP); serum creatinine, urine creatinine, creatinine/height index, percent arm muscle circumference; peripheral lymphocytes, white blood cells, complement (C3c), skin tests. In the cancer group percent usual body weight, percent arm muscle circumference, hematocrit, hemoglobin, albumin, iron, ceruloplasmin, retinol binding protein, C3c and delayed hypersensitivity response (DHR) were significantly different from controls. Ceruloplasmin and DHR were the only tests significantly different in the cancer patients who developed postoperative infections. Duration of anesthesia and operative field contamination are other important causative factors which, if associated with malnutrition, may determine a higher susceptibility to infections in surgical cancer patients.

Journal of Parenteral and Enteral Nutrition, Vol. 4, No. 4, 351-356 (1980)
DOI: 10.1177/014860718000400403


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