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Essential Fatty Acid Deficiency in Patients Receiving Simultaneous Parenteral and Oral Nutrition

From the Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, the Philadelphia Veterans Administration Hospital and the Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania

Gordon P. Buzby

From the Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, the Philadelphia Veterans Administration Hospital and the Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania

W. Clark Hargrove, III

From the Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, the Philadelphia Veterans Administration Hospital and the Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania

Maria J. Leskiw

From the Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, the Philadelphia Veterans Administration Hospital and the Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania

James L. Mullen

From the Surgical Research Laboratories, Graduate Hospital, University of Pennsylvania, the Philadelphia Veterans Administration Hospital and the Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania

Essential fatty acid deficiency is a common finding in patients nourished parenterally with hypertonic glucose and amino acids. In this study, we measured the Iinoleate concentration in the livers of 3 groups of patients. All the patients had operable upper gastrointestinal tract malignancies. Group I ate the hospital's regular diet ad libitum. Group II were given total parenteral nutrition (TPN). Group III received both enteral and parenteral nutrition and obtained about 35% of their caloric intake from food. The percentage of total liver fatty acids as linoleate were group I, 15.2 ± 1.2%, group II, 3.7 ± 1.4%, and group III, 2.8 ± 1.6%. Data are expressed as the mean ± 1 SEM. The patients who received 35% of their calories by mouth as food and the patients on TPN were found to be equally depleted in linoleate.

Journal of Parenteral and Enteral Nutrition, Vol. 4, No. 4, 343-345 (1980)
DOI: 10.1177/014860718000400401


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