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Journal of Parenteral and Enteral Nutrition
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Case Reports

Urinary 3 -Methylhistidine: Creatinine Ratio in Patients on Long-Term Parenteral Nutrition

Peter Milewski, M.B., B.Chir., F.R.C.S.

From the University Department of Surgery, Hope Hospital, Manchester, England

Ian Holbrook, B.SC, PH.D.

From the University Department of Surgery, Hope Hospital, Manchester, England

Miles Irving, M.D., CH.M., F.R.C.S.

From the University Department of Surgery, Hope Hospital, Manchester, England

ABSTRACT. The urinary 3-methylhistidine (3-MH) and creatinine excretion were measured serially in two patients on total parenteral nutrition for 201 and 225 days, respectively. Variations in excretion were related to clinical events, such as sepsis; 3-MH excretion and the 3-MH: creatinine ratio were raised in association with some episodes of infection, but not all. It is concluded that, although infection is often associated with increased myofibrillar protein breakdown, this is not always the case. It is suggested that in susceptible patients a high 3-MH:creatinine ratio may indicate occult infection not detectable by other means.

Journal of Parenteral and Enteral Nutrition, Vol. 4, No. 3, 286-289 (1980)
DOI: 10.1177/014860718000400308
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This article has been cited by other articles:


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 JPEN J Parenter Enteral NutrHome page
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 JPEN J Parenter Enteral NutrHome page
G. Iapichino, D. Radrizzani, M. Solca, G. Bonetti, L. Leoni, and A. Ferro
Influence of Total Parenteral Nutrition on Protein Metabolism following Acute Injury: Assessment by Urinary 3-Methylhistidine Excretion and Nitrogen Balance
JPEN J Parenter Enteral Nutr, January 1, 1985; 9(1): 42 - 46.
[Abstract] [PDF]