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Journal of Parenteral and Enteral Nutrition
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Original Communications

Effect of Sesame Oil on Acidified Ethanol-Induced Gastric Mucosal Injury in Rats

Dur-Zong Hsu, DVM, PhD1, Pei-Yi Chu, MS1 and Ming-Yie Liu, PhD1,2

From the 1 Department of Environmental and Occupational Health, National Cheng Kung University Medical College; and2 Sustainable Environment Research Center, National Cheng Kung University, Tainan, Taiwan.

Address correspondence to: Ming-Yie Liu, PhD, Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan 704 Taiwan; e-mail: myliu{at}mail.ncku.edu.tw.

Background: Exposure of gastric mucosa to concentrated ethanol induces acute gastritis. Gastric mucosal lipid peroxidation plays a significant role in the pathogenesis of ethanol-induced gastric mucosal lesions. The aim of this study was to investigate the effect of sesame oil on acidified ethanol-induced gastric mucosal damage in rats. Methods: We performed gastric bilateral vagotomy in rats. A small incision on forestomach was made and stomach content was expelled. Normal artificial gastric acid (54 mM NaCl plus 100 mM HCl) or acidified ethanol (30% ethanol plus 150 mM HCl) was instilled into the stomach. Gastric lipid peroxidation, glutathione, and nitric oxide levels were measured 3 hours after acidified ethanol administration. Results: Acidified ethanol caused mucosal ulceration, luminal hemorrhage, lipid peroxidation, and a lower level of mucosal glutathione and nitric oxide production. Pretreatment of sesame oil, but not mineral oil, significantly decreased acidified ethanol-induced mucosal ulcer formation and luminal hemorrhage. Sesame oil reduced mucosal lipid peroxidation, as well as glutathione and nitric oxide production in acidified ethanol-treated stomachs. Furthermore, both sesame oil and mineral oil did not affect serum ethanol concentration in acidified ethanol-treated rats. Conclusion: Sesame oil attenuates acidified ethanol-induced gastric mucosal injury by reducing oxidative stress in rats.

Key Words: ethanol • sesame oil • lipid peroxidation • gastric mucosal damage • glutathione • nitric oxide

This version was published on July 1, 2009

Journal of Parenteral and Enteral Nutrition, Vol. 33, No. 4, 423-427 (2009)
DOI: 10.1177/0148607108327046
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