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Journal of Parenteral and Enteral Nutrition
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Original Communications

Need for Thiamine in Peripheral Parenteral Nutrition After Abdominal Surgery in Children

Kouji Masumoto, MD, PhD1, Genshiro Esumi, MD1, Risa Teshiba, MD1, Kouji Nagata, MD1, Takanori Nakatsuji, MD, PhD1, Yuko Nishimoto, MD, PhD1, Satoshi Ieiri, MD, PhD1, Naoko Kinukawa, MS2 and Tomoaki Taguchi, MD, PhD1

From 1 Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, and 2 Department of Medical Information Science, Kyushu University Hospital, Fukuoka, Japan.

Address correspondence to: Kouji Masumoto, MD, PhD, Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan; e-mail: kmasu{at}pedsurg.med.kyushu-u.ac.jp.

Background: Thiamine blood concentrations of pediatric patients receiving peripheral parenteral nutrition change during the postoperative period. In addition, the need to administer thiamine after surgery has not yet been fully studied in children receiving peripheral parenteral nutrition. Objective: The objective of this prospective study is to clarify whether pediatric patients require the administration of thiamine while receiving peripheral parenteral nutrition after abdominal surgery. Patients: Fifteen children were divided into 2 groups; 1 group received peripheral parenteral nutrition without thiamine after surgery (n = 7), whereas the other group received peripheral parenteral nutrition with thiamine after surgery (n = 8). In both groups, thiamine blood concentrations were measured on the preoperative day, and changes in thiamine concentration over time were measured during the starvation period from the first to the fifth postoperative day. Results: Preoperative thiamine blood concentrations were within the normal range in both groups. In the group receiving peripheral parenteral nutrition without thiamine, the thiamine concentration gradually decreased with time after the operation, whereas the concentration remained within the normal range in the group receiving peripheral parenteral nutrition with thiamine. Among the 7 patients receiving peripheral parenteral nutrition without thiamine, the thiamine concentration in 3 patients was below the normal range on the fifth postoperative day. Conclusion: During the starvation period after abdominal surgery, thiamine blood concentrations decreased in pediatric patients receiving peripheral parenteral nutrition without thiamine. Therefore, clinicians treating pediatric patients should add thiamine to the peripheral parenteral nutrition solution during the short starvation period after abdominal surgery.

Key Words: peripheral parenteral nutrition • thiamine • surgery • children

This version was published on July 1, 2009

Journal of Parenteral and Enteral Nutrition, Vol. 33, No. 4, 417-422 (2009)
DOI: 10.1177/0148607108327391
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