This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gonçalves, C. G. Articles by Campos, A. C. L. Search for Related Content PubMed PubMed Citation Articles by Gonçalves, C. G. Articles by Campos, A. C. L. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Influence of Preoperative Feeding on the Healing of Colonic Anastomoses in Malnourished Rats

From the Department of Surgery, Hospital das Clinicas, Federal University of Paraná, Curitiba, PR, Brazil.

Address correspondence to: Carolina G. Gonçalves, MD, Department of Surgery, Federal University of Paraná, Angelo Sampaio 2692 Apt #63B, Curitiba, PR, Brazil, 80730-460; e-mail: carolgg{at}gmail.com.

Background: Malnutrition influences healing of gastrointestinal anastomoses. The authors hypothesize that colonic anastomotic healing is decreased by malnutrition and might be improved by preoperative feeding. Methods: Eighty adult male Wistar rats were divided into 4 groups: (1) control rats 1 (C1), fed regular chow ad libitum for 21 days; (2) malnourished pair-fed rats (M), fed 50% of the food ingested by the control rats for 21 days; (3) preoperative nutrition rats (PRE), fed 50% of the average of the controls for 21 days and then fed preoperative nutrition with regular chow ad libitum for 1 week before the operation; and (4) control rats 2 (C2), fed regular chow ad libitum for 28 days. On days 21 (C1 and M) and 28 (PRE and C2), rats underwent 2 colonic transections and, subsequently, 2 end-to-end anastomoses. Rats were killed on postoperative day 5. The anastomoses were ressected for tensile strength and histological analysis. Results: PRE rats showed increased maximal tensile strength vs the M group (0.09 ± 0.01 vs 0.15 ± 0.01; P < .05) and similar values of maximal tensile strength as the controls (0.15 ± 0.01 vs 0.15 ± 0.02; P = .91). Collagen type I was higher in controls vs the PRE group (6.13 ± 0.39 vs 4.90 ± 1.53; P < .05); nevertheless, the PRE group showed higher collagen type I than M rats (4.90 ± 0.36 vs 3.83 ± 0.35; P < .05). Conclusions: Preoperative feeding for 7 days increases the maximal tensile strength, as well as the percentage area of mature collagen, approaching similar values as the control group.

Key Words: protein energy malnutrition • perioperative care • anastomoses • healing • rats

Journal of Parenteral and Enteral Nutrition, Vol. 33, No. 1, 83-89 (2009)
DOI: 10.1177/0148607108327047


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?