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Journal of Parenteral and Enteral Nutrition
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2008 Research Workshop

Inflammation and Intestinal Function: Where Does It Start and What Does It Mean?

Kelly A. Tappenden, PhD, RD

From the Division of Nutritional Sciences and Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign.

Address correspondence to: Kelly A. Tappenden, PhD, RD, 443 Bevier Hall, 905 South Goodwin Avenue, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801; e-mail: tappende{at}uiuc.edu.

Various key elements of intestinal function, such as digestion, absorption, and barrier function, are impaired during inflammation. Although intestinal damage associated with inflammation originating within the intestine is well-known, inflammation in distant organs can impair intestinal function, despite normal histological appearance of the impacted intestinal mucosa. Widespread clinical dogma indicating that intestinal dysfunction drives inflammation should be reconsidered based on data indicating that, in many situations, inflammation precedes intestinal damage and appears to be the injurious factor. Finally, various nutrients have been shown to protect and/or repair the intestinal mucosa from the effects of inflammation; therefore, strategies for optimizing the nutrients provided during inflammatory states should be considered.

Key Words: inflammation • mucosa • nutrients • digestion • intestinal barrier function • entrocyte

Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 6, 648-650 (2008)
DOI: 10.1177/0148607108325177
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