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Nutrition and Age-Associated Inflammation: Implications for Disease Prevention

From the JMUSDA Human Nutrition Research Center on Aging at Tufts University and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts.

Address correspondence to: Simin Nikbin Meydani, Nutritional Immunology Laboratory, JMUSDA-HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111; e-mail: simin.meydani{at}tufts.edu.

Accumulating evidence suggests that aging is associated with dysregulated immune and inflammatory responses. Investigation into the cellular and molecular mechanisms underlying this phenomenon suggests that an up-regulated cyclooxygenase (COX)-2 expression, and resulting increase in production of prostaglandin E₂ (PGE₂), is a critical factor. Macrophages from old mice have significantly higher levels of PGE₂ production compared with those from young mice, a result of increased COX-2 expression and protein levels leading to increased COX enzyme activity. Furthermore, studies suggest that the age-associated increase in macrophage PGE₂ production is due to ceramide-induced up-regulation of nuclear factor- B activation. Such processes may also occur in cell types other than macrophages, lending further insight into potential mechanisms of age-related diseases. Moreover, the excess PGE₂ induces harmful effects in other cell types such as T cells and adipocytes through the negative crosstalk between macrophages with other cells, resulting in further increased susceptibility to diseases. Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE₂ production that is associated with several disease states.

Key Words: aging • inflammatory response • macrophages (M) • ceramide • sphingomyelinase • cyclooxygenase (COX)-2 • prostaglandin E₂ (PGE₂) • nuclear factor-kappa B (NFB)

Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 6, 626-629 (2008)
DOI: 10.1177/0148607108325179


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