Journal of Parenteral and Enteral Nutrition

 

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Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 2, 154-159 (2008)
DOI: 10.1177/0148607108314766
© 2008 The American Society for Parenteral and Enteral Nutrition

Original Communications

Sesame Oil Attenuates Hepatic Lipid Peroxidation by Inhibiting Nitric Oxide and Superoxide Anion Generation in Septic Rats

Dur-Zong Hsu, PhD1, Se-Ping Chien, MS4, Ya-Hui Li, MS1, Yin-Ching Chuang, MD5, Yu-Chung Chang, MD, PhD3 and Ming-Yie Liu, PhD1,2

From the 1 Department of Environmental and Occupational Health, 2 Sustainable Environment Research Centre, and 3 Department of Surgery, National Cheng Kung University Medical College, Tainan, Taiwan;4 Department of Living Science, Tainan University of Technology, Tainan, Taiwan; and 5 Department of Medicine, Chi-Mei Medical Center, Tainan, Taiwan.

Address correspondence to: Ming-Yie Liu, Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan 704, Taiwan; e-mail: myliu{at}mail.ncku.edu.tw.

Background: Sepsis is a major cause of mortality in the intensive care unit. Oxidative stress plays an important role in the pathogenesis of organ failure during sepsis. Sesame oil decreases circulating oxygen free radicals in septic rats; however, its effect on hepatic oxidative status is unknown. The authors examined the effect of sesame oil on hepatic lipid peroxidation in septic rats. Methods: Hepatic injury was induced using cecal ligation and puncture (CLP). Rats were divided into 4 groups: sham, rats given a sham operation without CLP; SO, rats given sesame oil alone; CLP, rats given saline and then CLP; and CS, rats given sesame oil and then CLP. All rats were first given a 1-week daily oral supplement of sesame oil or saline (4 mL/kg/d) and then CLP or a sham operation. The authors assessed hepatic oxidative stress by determining hepatic lipid peroxidation, hydroxyl radical, superoxide anion, and nitric oxide levels 12 hours after CLP. They also assessed xanthine oxidase activity and nitric oxide synthase expression. Results: Hepatic lipid peroxidation (P < .0001), hydroxyl radical (P < .05), superoxide anion (P < .05), and nitrite (P < .05) levels were significantly lower in sesame oil–treated septic rats. Furthermore, sesame oil significantly reduced xanthine oxidase activity (P < .01) and inducible nitric oxide synthase expression (P < .005) in septic rats. Conclusions: Sesame oil might attenuate hepatic lipid peroxidation by inhibiting superoxide anion and nitric oxide, at least partially, in experimental septic rats.

Key Words: liver • lipid peroxidation • reactive oxygen species • nitric oxide • sepsis • sesame oil


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