Journal of Parenteral and Enteral Nutrition

 

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Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 1, 98-100 (2008)
DOI: 10.1177/014860710803200198

Brief Communications

Effect of Liquid Pancreatic Enzymes on the Assimilation of Fat in Different Liquid Formula Diets

Annette Hauenschild, PhD, Nils Ewald, MD, Thorsten Klauke, MD, Ariane Liebchen, PhD, Reinhard Georg Bretzel, MD, Hans-Ulrich Kloer, MD and Philip Daniel Hardt, MD

From the Third Medical Department, University Hospital Giessen und Marburg, Giessen, Germany

Correspondence: Nils Ewald, MD, Third Medical Department, University Hospital Giessen and Marburg, Giessen Site, Rodthohl 6, D-35392 Giessen, Germany. Electronic mail may be sent to nils.ewald{at}innere.med.uni-giessen.de.

Background: In some diseases, patients require high-calorie tube feeding with standard enteral formulas usually administered via temporal feeding tubes. One frequent pathophysiological condition in a relevant number of these patients is exocrine pancreatic insufficiency. Patients unable to swallow capsules might benefit from a liquid pancreatic enzyme (LPE) preparation. Methods: LPEs were prepared and mixed with different commercially available formula diets produced for enteral feeding. Lipolysis was then measured by fatty acid titration. Results: Complete lipolysis by liquid enzyme preparations was observed in diverse formula diets. Fat assimilation was even complete when LPE had been prepared 3.5 hours before the experiments, showing that the enzymes had been stable up to that time. Conclusions: The use of LPEs seems to be a good therapeutic option in patients with exocrine pancreatic insufficiency and the need for permanent high-calorie enteral feeding. Pharmaceutical companies should therefore be further encouraged to develop and distribute liquid enzyme preparations.


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