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Thromboembolism in Infants and Children With Gastrointestinal Failure Receiving Long-Term Parenteral Nutrition

Vered Kakzanov, BSc^*, Paul Monagle, MD and Anthony K. C. Chan, MBBS

From the ^* Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Pathology, University of Melbourne, and Department of Haematology, Royal Children's Hospital, Melbourne, Victoria, Australia; Division of Pediatric Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada, and the Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

Correspondence: Anthony K. C. Chan, MBBS, Division of Pediatric Hematology/Oncology, Department of Pediatrics, McMaster University, 1200 Main Street W, Hamilton, ON, Canada. Electronic mail may be sent to akchan{at}mcmaster.ca.

Thromboembolism is an established complication of long-term parenteral nutrition (PN) administration which requires central venous lines in the pediatric population. Predisposing factors that increase the risk of thrombosis, as well as prophylaxis and treatment guidelines in this specific population, are not clearly defined. We performed a computerized search of PubMed, OVID databases, and pertinent articles from reference lists of related review papers. This review summarizes currently available data on the rates of thromboembolism in the pediatric population receiving long-term PN and concludes that control of factors such as location of catheter, duration of nutrition support, and prophylaxis with heparin or anticoagulants may reduce the rates of thrombosis in this patient population, although most data on the matter are inconclusive.

Journal of Parenteral and Enteral Nutrition, Vol. 32, No. 1, 88-93 (2008)
DOI: 10.1177/014860710803200188


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