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Journal of Parenteral and Enteral Nutrition
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Original Communications

Autopsy Tissue Trace Elements in 8 Long-Term Parenteral Nutrition Patients Who Received the Current U.S. Food and Drug Administration Formulation

Lyn Howard, MB, FRCP*, Christopher Ashley, MD, MPH*, David Lyon, PhD{dagger} and Alan Shenkin, PhD, FRCPath{ddagger}

From the * Department of Medicine, Division of Gastroenterology and Nutrition, Albany Medical College, Albany, New York;{dagger} Department of Clinical Biochemistry, Royal Infirmary Glasgow, United Kingdom; and the{ddagger} Department of Clinical Chemistry, University of Liverpool, Liverpool, United Kingdom

Correspondence: Lyn Howard, MB, FRCP, Department of Medicine, Albany Medical College, Albany, NY 12208. Electronic mail may be sent to harrinc{at}mail.amc.edu.

Iron, zinc, copper, manganese, chromium, and selenium levels were measured in autopsy tissues of 8 people with short bowel syndrome who received home parenteral nutrition (HPN) and the U.S. Food and Drug Administration (FDA)– approved trace element formulation for an average duration of 14 years (range, 2–21). Iron, zinc, copper, manganese and selenium were measured by inductively coupled plasma methods; chromium, by graphite furnace atomic absorption spectrometry. The levels in the 4 tissues studied, heart, skeletal muscle, liver, and kidney, were compared with levels in 45 controls who died without chronic gastrointestinal disorders. Results showed normal HPN patient values for iron and selenium, mild elevation of zinc, and major elevations of copper, manganese, and chromium. The implications of these results for trace-element supplements in long-term PN adult patients are discussed, and the need for reformulation of commercially available multi–trace element products in the United States is stressed.

Journal of Parenteral and Enteral Nutrition, Vol. 31, No. 5, 388-396 (2007)
DOI: 10.1177/0148607107031005388
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